ArticlePeerJ2016
In vitro evaluation of antifungal activity of monolaurin against Candida albicans biofilms.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Evaluation of the Antifungal Activity of the Polyphenol FormulationAntibiotics (Basel, Switzerland) · 2026Article
- Metabolomic profiling reveals alterations in Candida pathophysiology and host interactions during primary oral candidiasis and following antifungal treatment.Scientific reports · 2026Article
- Dietary glycerol monolaurate mitigates heat stress-induced disruption of intestinal homeostasis and hepatic lipid metabolism in laying hens.Stress biology · 2025Article
- New Curcumin Analogue (PAC) InhibitsAntibiotics (Basel, Switzerland) · 2025Article
- Higher Serum Monolaurin Is Associated with a Lower Risk of COVID-19: Results from a Prospective Observational Cohort Study.International journal of molecular sciences · 2025Observational
- Ascorbic Acid Enhances the Inhibitory Effect of Theasaponins againstInternational journal of molecular sciences · 2024Article
- Nature-Derived Gelatin-Based Antifungal Nanotherapeutics for combattingEnvironmental science. Nano · 2024Article
- Monoterpene antifungal activities: evaluating geraniol, citronellal, and linalool onFrontiers in pharmacology · 2024Article
- Syzygium aromaticum essential oil and its major constituents: Assessment of activity against Candida spp. and toxicity.PloS one · 2024Article
- Effects of combined application of benzoic acid and 1-monolaurin on growth performance, nutrient digestibility, gut microbiome and inflammatory factor levels in weaned piglets.Porcine health management · 2023Article
- Healthy Diet and Lifestyle Improve the Gut Microbiota and Help Combat Fungal Infection.Microorganisms · 2023Review
- New Technologies to Diagnose and Treat a Multidrug-Resistant Candida auris: A Patent Review.Mycopathologia · 2022Review
- Article
- Effects of α-glyceryl monolaurate on growth, immune function, volatile fatty acids, and gut microbiota in broiler chickens.Poultry science · 2021Article
- Yeast-Host Interactions:Frontiers in pharmacology · 2021Article
- Bioactive Dental Adhesive System WithFrontiers in bioengineering and biotechnology · 2020Article
- The 1-monolaurin inhibit growth and eradicate the biofilm formed by clinical isolates ofBMC proceedings · 2019Article
- Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity.Asian journal of pharmaceutical sciences · 2018Article
- Fungal-Host Interaction: Curcumin Modulates Proteolytic Enzyme Activity ofInternational journal of dentistry · 2018Article
- Effects of Monolaurin on Oral Microbe-Host Transcriptome and Metabolome.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Monolaurin (also known as glycerol monolaurate) is a natural compound found in coconut oil and is known for its protective biological activities as an antimicrobial agent. The nature of oral candidiasis and the increased antifungal resistance demand the search for novel antifungal therapeutic agents. In this study, we examine the antifungal activity of monolaurin against Candida albicans biofilms (strain ATCC:SC5314/MYA2876) in vitro and investigate whether monolaurin can alter gene expression of host inflammatory cytokines, IL-1α and IL-1β. In a co-culture model, oral fibroblast cells were cultured simultaneously with C. albicans for 24 hrs followed by the exposure to treatments of monolaurin (3.9-2,500 µM), positive control fluconazole (32.2 µM), and vehicle control group (1% ethanol), which was a model used to evaluate the cytotoxicity of monolaurin on fibroblasts as well as to analyze morphological characteristics of biofilms through fluorescence microscopy. In addition, the co-culture model was used for RNA extraction of oral fibroblasts to assess gene expression of host inflammatory cytokines, using quantitative real-time PCR. Our results showed the MIC and MFC of monolaurin were in the range 62.5-125 µM and 125-250 µM, respectively. Biofilm antifungal assay showed significant reduction in Log (CFU/ml) of biofilms treated with 1,250 and 2,500 µM of 1-monolaurin when compared to the control groups . There was also a significant down-regulation of IL-1α and IL-1β in the co-culture treated with monolaurin. It can be concluded that monolaurin has a potential antifungal activity against C. albicans and can modulate the pro-inflammatory response of the host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.