Evidence map›Paper›PMID 27366161›Full record

ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2016

HIV Prophylaxis in High Risk Newborns: An Examination of Sociodemographic Factors in an Inner City Context.

Zenita Alidina, Anne E Wormsbecker, Marcelo Urquia, Jay MacGillivray, Evan Taerk, Mark H Yudin, Douglas M Campbell

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zenita AlidinaSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8.
Anne E WormsbeckerSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8; Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8; Department of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.
Marcelo UrquiaSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada M5T 3M7; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada M5B 1T8.
Jay MacGillivraySt. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8.
Evan TaerkSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8.
Mark H YudinSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8; Department of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada M5B 1T8.
Douglas M CampbellSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8; Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8; Department of Medicine, University of Toronto, Toronto, ON, Canada M5S 1A8.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Perinatal HIV transmission is less than 1% with antiretroviral (ARV) prophylaxis. Transmission risk appears higher in "high risk" dyads, yet this is not well defined, possibly exposing more infants to combination ARV compared with standard care. Objective. To describe characteristics of mother-infant dyads where infants received ARVs and how these characteristics relate to specific ARV regimens. Methods. Retrospective chart review of ARV-receiving newborns at St. Michael's Hospital from 2007 to 2012 (and their mothers). Numerical and categorical variables were analyzed using t-tests/ANOVA F-tests and Fisher's exact tests, respectively. Results. Maternal HIV status at delivery was as follows: 69% positive and 24% unknown. Maternal factors significantly associated with newborn-triple therapy are Canadian origin, substance abuse, unstable housing, lost custody of previous children, and sex work. Neonatal factors are child protective services involvement, NICU, and lengthier admission. Maternal factors associated with monotherapy are African origin, HIV-positive, employment, and education. Further analysis based on maternal presentation at delivery demonstrated unequal distribution of many aforementioned factors. Discussion. This cohort revealed associations between particular factors and newborn-monotherapy or triple therapy that exist, suggesting that sociodemographic factors may influence the choice of ARV regimen. Canadian perinatal HIV transmission guidelines should qualify how to risk stratify newborns and consider use of rapid HIV antibody testing.

Identifiers

PMID27366161
PMCPMC4904583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.