ArticleNeuropsychiatric disease and treatment2016
Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study.
Article in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 7 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 7 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Potential Targets for Scalp Acupuncture and Brain Stimulation in Mental Disorders: Evidence From Large-Scale Meta-Analyses.Alpha psychiatry · 2026Pooled it
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.Brain imaging and behavior · 2025Pooled it
- Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Effect-size seed-based d mapping of resting-state fMRI for persistent insomnia disorder.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis.Sleep medicine reviews · 2018Pooled it
- Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI.Neuroscience and biobehavioral reviews · 2017Pooled it
- Effectiveness and cerebral responses of multi-points acupuncture for primary insomnia: a preliminary randomized clinical trial and fMRI study.BMC complementary medicine and therapies · 2020Trial
- Efficacy and neural mechanisms of transcutaneous auricular vagus nerve stimulation for chronic insomnia: a study protocol for a randomized controlled trial.Frontiers in psychiatry · 2026Article
- Impaired emotional processing in insomnia: REM sleep beta power and frontal cortex activation.BMC medicine · 2025Article
- Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder.BMC medicine · 2025Article
- Abnormal sensory processing cortex in insomnia disorder: a degree centrality study.Brain imaging and behavior · 2025Observational
- Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger's disease with mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Altered connection properties of the left dorsolateral superior frontal gyrus inFrontiers in neuroscience · 2025Article
- Cerebellar-limbic dysregulation and sensorimotor network alterations in male primary insomnia: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2025Article
- The abnormalities of brain function in females with primary insomnia: a resting-state functional magnetic resonance imaging study.Frontiers in neuroscience · 2024Article
- Multi-level exploration of auricular acupuncture: from traditional Chinese medicine theory to modern medical application.Frontiers in neuroscience · 2024Review
- Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.Frontiers in neuroscience · 2024Article
- Abnormal alterations of regional spontaneous neuronal activity and functional connectivity in insomnia patients with difficulty falling asleep: a resting-state fMRI study.BMC neurology · 2023Article
- Altered functional connectivity of the default mode and frontal control networks in patients with insomnia.CNS neuroscience & therapeutics · 2023Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInvestigating functional specialization is crucial for a complete understanding of the neural mechanisms of primary insomnia (PI). Resting-state functional magnetic resonance imaging (fMRI) is a useful tool to explore the functional specialization of PI. However, only a few studies have focused on the functional specialization of PI using resting-state fMRI and results of these studies were far from consistent. Thus, the current study aimed to investigate functional specialization of PI using resting-state fMRI with amplitude of low frequency fluctuations (ALFFs) algorithm.
methodsIn this study, 55 PI patients and 44 healthy controls were included. ALFF values were compared between the two groups using two-sample t-test. The relationship of abnormal ALFF values with clinical characteristics and duration of insomnia was investigated using Pearson's correlation analysis.
resultsPI patients showed lower ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, right middle frontal gyrus, left inferior parietal lobule, and bilateral cerebellum posterior lobes, while higher ALFF values in the right middle/inferior temporal that extended to the right occipital lobe. In addition, we found that the duration of PI negatively correlated with ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, and the Pittsburgh Sleep Quality Index score negatively correlated with ALFF values in the left inferior parietal lobule.
conclusionThe present study added information to limited studies on functional specialization and provided evidence for hyperarousal hypothesis in PI.
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