ArticleAnnals of gastroenterology
Pre-endoscopic erythromycin administration in upper gastrointestinal bleeding: an updated meta-analysis and systematic review.
Article in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Role of prokinetic drugs prior to endoscopy in acute upper gastrointestinal bleeding: a systematic review and meta-analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Pooled it
- Timing of endoscopy in patients with acute variceal bleeding in cirrhosis: an updated systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Erythromycin Improves the Quality of Esophagogastroduodenoscopy in Upper Gastrointestinal Bleeding: A Network Meta-Analysis.Digestive diseases and sciences · 2023Pooled it
- Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage.The Cochrane database of systematic reviews · 2023Pooled it
- Intravenous metoclopramide for increasing endoscopic mucosal visualization in patients with acute upper gastrointestinal bleeding: a multicenter, randomized, double-blind, controlled trial.Scientific reports · 2024Trial
- Endoscopic Treatment of Upper Gastrointestinal Bleeding.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Management of Non-Variceal Upper Gastrointestinal Bleeding.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Pre-endoscopy erythromycin versus metoclopramide for upper gastrointestinal bleeding: a systematic review and network meta-analysis.Clinical endoscopy · 2025Article
- Advances in the diagnosis and management of clinically significant portal hypertension in cirrhosis: A narrative review.World journal of hepatology · 2025Review
- Position statement of the Polish Society of Gastroenterology on the use of andexanet alfa in patients with gastrointestinal bleeding taking factor Xa inhibitors.Przeglad gastroenterologiczny · 2025Article
- [Non-Variceal Upper Gastrointestinal Bleeding].The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- [Gastrointestinal bleeding in old age].Zeitschrift fur Gerontologie und Geriatrie · 2024Article
- Acute upper and lower gastrointestinal bleeding management in older people taking or not taking anticoagulants: a literature review.Frontiers in medicine · 2024Review
- Utility of gastroscopy in the left lateral semi-recumbent position: A blood-free coup!Endoscopy international open · 2023Article
- An update on the management of non-variceal upper gastrointestinal bleeding.Gastroenterology report · 2023Review
- A Novel Prediction Tool for Endoscopic Intervention in Patients with Acute Upper Gastro-Intestinal Bleeding.Journal of clinical medicine · 2022Article
- Update on the management of upper gastrointestinal bleeding.BMJ medicine · 2022Review
- Management of Non-Variceal Upper GI Bleeding in the Geriatric Population: An Update.Current gastroenterology reports · 2021Review
- Bleeding Duodenal Ulcer: Strategies in High-Risk Ulcers.Visceral medicine · 2021Review
- Oral Erythromycin Improves the Quality of Endoscopy in Upper Gastrointestinal Bleeding Patients.Cureus · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients suffering from upper gastrointestinal bleeding (UGIB), adequate visualization is essential during endoscopy. Prior to endoscopy, erythromycin administration has been shown to enhance visualization in these patients; however, guidelines have not fully adopted this practice. Thus, we performed a comprehensive, up-to-date meta-analysis on the issue of erythromycin administration in this patient population.
methodsAfter searching multiple databases (November 2015), randomized controlled trials on adult subjects comparing administration of erythromycin before endoscopy in UGIB patients to no erythromycin or placebo were included. Pooled estimates of adequacy of gastric mucosa visualized, need for second endoscopy, duration of procedure, length of hospital stay, units of blood transfused, and need for emergent surgery using odds ratio (OR) or mean difference (MD) were calculated. Heterogeneity and publication bias were assessed.
resultsEight studies (n=598) were found to meet the inclusion criteria. Erythromycin administration showed statistically significant improvement in adequate gastric mucosa visualization (OR 4.14; 95% CI: 2.01-8.53, P<0.01) while reduced the need for a second-look endoscopy (OR 0.51; 95% CI: 0.34-0.77, P<0.01) and length of hospital stay (MD -1.75; 95% CI: -2.43 to -1.06, P<0.01). Duration of procedure (P=0.2), units of blood transfused (P=0.08), and need for emergent surgery (P=0.88) showed no significant differences.
conclusionPre-endoscopic erythromycin administration in UGIB patients significantly improves gastric mucosa visualization while reducing length of hospital stay and the need for second-look endoscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.