Evidence map›Paper›PMID 27365963›Full record

ArticleJournal of neurosciences in rural practice

Assessment of intracranial metastases from neuroendocrine tumors/carcinoma.

Ahmed M Ragab Shalaby, Hoshi Kazuei, Honma Koichi, Saeed Naguib, Lubna A Al-Menawei

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Journal of neurosciences in rural practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ahmed M Ragab ShalabyDepartment of Oncologic Pathology, Kameda Hospital and Oncology Center, Kamogawa Chiba, Japan.
Hoshi KazueiDepartment of Oncologic Pathology, Kameda Hospital and Oncology Center, Kamogawa Chiba, Japan.
Honma KoichiDepartment of Oncologic Pathology, Kameda Hospital and Oncology Center, Kamogawa Chiba, Japan.
Saeed NaguibDepartment of Immunology, Damanhour National Medical Institute, Damanhour, Egypt.
Lubna A Al-MenaweiDepartment of Pathology, KAAZ Hospital and Oncology Center, Jeddah, Saudi Arabia.
Kameda Medical Center · JPDamanhour University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe most common sites of origin for neuroendocrine carcinoma are gastrointestinal tract and its accessory glands, and lungs. MATERIALS AND

methodsOne-hundred fifty cases diagnosed with metastatic brain lesions were retrieved from hospital records within 5 years. For these cases, the primary neoplasm, histopathological classification, metastasis, treatment, and fate all were studied.

resultsIntracranial deposits were detected in 10%. The primary lesion was in the lungs in 87% of patients, and 1 patient in the breast and 1 in esophagus. Pathological classification of the primary lesion was Grade 2 (MIB-1: 3-20%) in 1 patient and neuroendocrine carcinoma (MIB-1: ≥21%) in 14 patients. The median period from onset of the primary lesion up to diagnosis of brain metastasis was 12.8 months. About 33% of patients had a single metastasis whereas 67% patients had multiple metastases. Brain metastasis was extirpated in 33% of patients. Stereotactic radiotherapy alone was administered in 20% of patients, and brain metastasis was favorably controlled in most of the patients with coadministration of cranial irradiation as appropriate. The median survival period from diagnosis of brain metastasis was 8.1 months.

conclusionMost of patients with brain metastasis from neuroendocrine carcinoma showed the primary lesion in the lungs, and they had multiple metastases to the liver, lymph nodes, bones, and so forth at the time of diagnosis of brain metastasis. The guidelines for accurate diagnosis and treatment of neuroendocrine carcinoma should be immediately established based on further analyses of those patients with brain metastasis.

Indexed as

Intracranial metastasesneuroendocrine carcinomaradiotherapy

Identifiers

PMID27365963
PMCPMC4898114
OpenAlexW2404171798

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.