ArticleJournal of neurosciences in rural practice
Deadly intracranial bleed in patients with dengue fever: A series of nine patients and review of literature.
Article in Journal of neurosciences in rural practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Intracerebral Haemorrhage in Patients With Dengue Fever: A Systematic Review and Meta-Analysis.Reviews in medical virology · 2025Pooled it
- Severe dengue, aneurysmal sub-arachnoid hemorrhage, and hemophagocytic lymphohistiocytosis: a rare case combination.Einstein (Sao Paulo, Brazil) · 2025Article
- Ischemic Stroke During Dengue Infection: A Report of 2 Cases.The American journal of case reports · 2023Article
- The burden, risk factors and unique etiologies of stroke in South-East Asia Region (SEAR).The Lancet regional health. Southeast Asia · 2023Review
- A Critical Analysis of Intracranial Hemorrhage as a Fatal Complication of Dengue Fever.Journal of Korean Neurosurgical Society · 2023Article
- Expanded dengue syndrome presenting with acute liver failure, acute kidney injury, pancreatic involvement, coagulopathy, and multiple intracranial hemorrhages in a young child: a case report.Journal of medical case reports · 2022Article
- Expanded Dengue Syndrome: A Case of Subarachnoid Haemorrhage, Cranial Diabetes Insipidus, and Haemophagocytic Lymphohistiosis.Case reports in infectious diseases · 2021Article
- Severe dengue categories as research endpoints-Results from a prospective observational study in hospitalised dengue patients.PLoS neglected tropical diseases · 2020Observational
- Beyond thrombocytopaenia, haemorrhage and shock: the expanded dengue syndrome.Pathogens and global health · 2018Review
- Case Report: Right Hemispheric Neuroimaging Abnormalities in a Patient with Dengue Encephalopathy.The American journal of tropical medicine and hygiene · 2018Article
- Risk of stroke in patients with dengue fever: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Cortical laminar necrosis in dengue encephalitis-a case report.BMC neurology · 2017Article
- Burden of Dengue-related Neurosurgical Emergencies during an Epidemic: A Tertiary Care Experience.Asian journal of neurosurgeryArticle
- Spontaneous intracranial hemorrhage associated with dengue fever: An emerging concern for general physicians.Journal of family medicine and primary careArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDengue fever is a global pandemic threat with increasing incidence. To date, there are no cures and the effectiveness of dengue vaccines is still uncertain. World Heath Organization introduced expanded dengue syndrome to include unusual presentations of dengue fever including severe neurologic complications. One of the deadly complications is intracranial hemorrhage (ICH). METHODOLOGY: We collected data of patients with ICH diagnosed via a plain computed tomography of the brain (CT brain) with thrombocytopenia and positive Dengue virus type 1 nonstructural protein (NS1) antigen test or positive dengue serology IgM from January 2014 till June 2015 at our center. Nine patients were included and all 20 other remaining patients reported in literature so far are discussed. DISCUSSION: We found that all patients in our center requiring neurosurgical intervention died. Another interesting observation is that detection of Dengue IgG usually meant more severe ICH and poorer outcomes. From our series, platelet levels did not seem to influence the outcome.
conclusionWe recommend that for early detection of ICH, Dengue IgG should be routinely screened and a high index of suspicion be maintained. Future research should be focused on determining predictors of ICH in patients with dengue fever so that preventive steps can be taken as mortality is high and no treatment seems beneficial at the moment once severe ICH occurs.
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