ArticleArteriosclerosis, thrombosis, and vascular biology2016
Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Network medicine: an approach to complex kidney disease phenotypes.Nature reviews. Nephrology · 2023Review
- Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023Review
- A 3-Mbp fragment on rat chromosome 1 affects susceptibility both to stroke and kidney injury under salt loading in the stroke-prone spontaneously hypertensive rat: a genetic approach using multiple congenic strains.Experimental animals · 2022Article
- Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension.Circulation research · 2021Article
- An Insight on Multicentric Signaling of Angiotensin II in Cardiovascular system: A Recent Update.Frontiers in pharmacology · 2021Review
- Article
- Splenocyte transfer exacerbates salt-sensitive hypertension in rats.Experimental physiology · 2020Article
- The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.The American journal of pathology · 2019Article
- TAM receptors in cardiovascular disease.Cardiovascular research · 2019Review
- Reporting Sex and Sex Differences in Preclinical Studies.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.The American journal of pathology · 2018Article
- Renin-Angiotensin System and Cardiovascular Functions.Arteriosclerosis, thrombosis, and vascular biology · 2018Review
- Novel adaptive and innate immunity targets in hypertension.Pharmacological research · 2017Review
- Loss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background.Hypertension (Dallas, Tex. : 1979) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveSurvival of immune and nonimmune cells relies on Axl, a receptor tyrosine kinase, which is implicated in hypertension. Activated T lymphocytes are involved in regulation of high blood pressure. The goal of the study was to investigate the role of Axl in T-lymphocyte functions and its contribution to salt-dependent hypertension. APPROACH AND
resultsWe report increased apoptosis in peripheral blood from Axl(-/-) mice because of lower numbers of white blood cells mostly lymphocytes. In vitro studies showed modest reduction in interferon gamma production in Axl(-/-) type 1 T helper cells. Axl did not affect basic proliferation capacity or production of interleukin 4 in Axl(-/-) type 2 T helper cells. However, competitive repopulation of Axl(-/-) bone marrow or adoptive transfer of Axl(-/-) CD4(+) T cells to Rag1(-/-) mice showed robust effect of Axl on T lymphocyte expansion in vivo. Adoptive transfer of Axl(-/-) CD4(+) T cells was protective in a later phase of deoxycorticosterone-acetate and salt hypertension. Reduced numbers of CD4(+) T cells in circulation and in perivascular adventitia decreased vascular remodeling and increased vascular apoptosis in the late phase of hypertension.
conclusionsThese findings suggest that Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
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Registered trials
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