ArticleThe Journal of biological chemistry2016
20-Hydroxyecdysone (20E) Primary Response Gene E75 Isoforms Mediate Steroidogenesis Autoregulation and Regulate Developmental Timing in Bombyx.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 82 citations in OpenAlex.
- AZoological research · 2026Article
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- Histone acetylation homeodynamics navigates cell survival and apoptosis.Nature communications · 2025Article
- Lipid metabolites affected by deficient autophagy antagonize the occurrence of autophagy through AMPK signaling in insects.BMC biology · 2025Article
- Nutrient status alters developmental fates via a switch in mitochondrial homeodynamics.Nature communications · 2025Article
- Modulation of host lipid metabolism by virus infection leads to exoskeleton damage in shrimp.PLoS pathogens · 2024Article
- Article
- The nuclear receptor gene E75 plays a key role in regulating the molting process of the spider mite, Tetranychus urticae.Experimental & applied acarology · 2024Article
- 5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 expression.Nature communications · 2023Article
- Research Progress on the Regulation of Autophagy and Apoptosis in Insects by Sterol Hormone 20-Hydroxyecdysone.Insects · 2023Review
- Overexpression ofInternational journal of molecular sciences · 2023Article
- Sterol Regulation of Development and 20-Hydroxyecdysone Biosynthetic and Signaling Genes inCells · 2023Article
- Adenosine Monophosphate-Activated Protein Kinase (AMPK) Phosphorylation Is Required for 20-Hydroxyecdysone Regulates Ecdysis inInternational journal of molecular sciences · 2023Article
- Functional Characterization of the Nuclear Receptor GeneInsects · 2023Article
- A Single Nucleotide Variant in the PPARγ-homolog Eip75B Affects Fecundity in Drosophila.Molecular biology and evolution · 2023Article
- Protein modification regulated autophagy inFrontiers in physiology · 2023Review
- A critical role for ecdysone response genes in regulating egg production in adult female Rhodnius prolixus.PloS one · 2023Article
- Conceptual framework for the insect metamorphosis from larvae to pupae by transcriptomic profiling, a case study of Helicoverpa armigera (Lepidoptera: Noctuidae).BMC genomics · 2022Article
- Transcription and Post-translational Regulation of Autophagy in Insects.Frontiers in physiology · 2022Article
- Advances in Editing Silkworms (Insects · 2021Review
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Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The temporal control mechanisms that precisely control animal development remain largely elusive. The timing of major developmental transitions in insects, including molting and metamorphosis, is coordinated by the steroid hormone 20-hydroxyecdysone (20E). 20E involves feedback loops to maintain pulses of ecdysteroid biosynthesis leading to its upsurge, whereas the underpinning molecular mechanisms are not well understood. Using the silkworm Bombyx mori as a model, we demonstrated that E75, the 20E primary response gene, mediates a regulatory loop between ecdysteroid biosynthesis and 20E signaling. E75 isoforms A and C directly bind to retinoic acid receptor-related response elements in Halloween gene promoter regions to induce gene expression thus promoting ecdysteroid biosynthesis and developmental transition, whereas isoform B antagonizes the transcriptional activity of isoform A/C through physical interaction. As the expression of E75 isoforms is differentially induced by 20E, the E75-mediated regulatory loop represents a fine autoregulation of steroidogenesis, which contributes to the precise control of developmental timing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.