ArticleAmerican journal of epidemiology2016
Detectable Risks in Studies of the Fetal Benefits of Maternal Influenza Vaccination.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Trivalent influenza vaccination randomized control trial of pregnant women and adverse fetal outcomes.Vaccine · 2019Trial
- Contribution of Serologic Assays in the Evaluation of Influenza Virus Infection Rates and Vaccine Efficacy in Pregnant Women: Report From Randomized Controlled Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Trial
- Article
- The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection.Pathogens (Basel, Switzerland) · 2019Review
- Measurement of birth outcomes in analyses of the impact of maternal influenza vaccination.Influenza and other respiratory viruses · 2019Article
- Inactivated influenza vaccine and spontaneous abortion in the Vaccine Safety Datalink in 2012-13, 2013-14, and 2014-15.Vaccine · 2019Article
- A pilot study showing a stronger H1N1 influenza vaccination response during pregnancy in women who subsequently deliver preterm.Journal of reproductive immunology · 2019Article
- Burden, effectiveness and safety of influenza vaccines in elderly, paediatric and pregnant populations.Therapeutic advances in vaccines and immunotherapy · 2019Review
- Article
- Making fair comparisons in pregnancy medication safety studies: An overview of advanced methods for confounding control.Pharmacoepidemiology and drug safety · 2018Review
- Influenza epidemiology and immunization during pregnancy: Final report of a World Health Organization working group.Vaccine · 2017Article
- Association of influenza vaccination during pregnancy with birth outcomes in Nicaragua.Vaccine · 2017Observational
- THE AUTHORS REPLY.American journal of epidemiology · 2017Article
- Article
- Hutcheon et al. Respond to "Maternal Influenza Immunization and Birth Outcomes".American journal of epidemiology · 2016Article
- Maternal Influenza Immunization and Adverse Birth Outcomes: Using Data and Practice to Inform Theory and Research Design.American journal of epidemiology · 2016Article
- The safety of maternal immunization.Human vaccines & immunotherapeutics · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Maternal influenza vaccination prevents influenza illness in both mothers and newborns. Results from some recent studies have suggested that influenza vaccination might also prevent adverse pregnancy outcomes, such as preterm birth. However, it is challenging to conduct epidemiologic studies to evaluate the benefits to the fetus of maternal influenza vaccination because the causal benefit of vaccination is likely only experienced by the small fraction of the cohort in whom influenza illness is prevented by vaccination. The plausibility of detecting true differences in risks between groups under such conditions is rarely discussed. We aimed to inform the interpretation of studies in which the fetal benefits of maternal influenza vaccination are evaluated by estimating detectable risk ratios and necessary sample sizes for different study scenarios. Estimates of rates of influenza illness, vaccine effectiveness, vaccine uptake, and preterm birth and of the association of influenza illness with preterm birth were identified from the published literature. We calculated detectable risk ratios for preterm birth in vaccinated versus unvaccinated women and the associated sample size requirements. Our results demonstrated that under most scenarios, plausible differences between groups will be extremely challenging to detect (risk ratios for preterm birth of 0.9 to 1.0) and will require sample sizes infeasible for prospective epidemiologic research. This suggests that the large fetal benefits from influenza vaccination observed in epidemiologic studies are unlikely to be causal.
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