ArticleAngewandte Chemie (International ed. in English)2016
Sequence-Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Efficient Solution-Phase Synthesis of Sequence-Defined Oligourethanes with Precise Chirality Control.Macromolecular rapid communications · 2025Article
- Bactericidal Biodegradable Linear Polyamidoamines Obtained with the Use of Endogenous Polyamines.International journal of molecular sciences · 2024Article
- Informational Polymers with Precise Carbamate Sequences.Precision chemistry · 2023Article
- Discrete Oligocarbamates Exhibit Sequence-Dependent Fluorescence Emission and Quenching.ACS polymers Au · 2023Article
- Iridium-Catalyzed Synthesis of Chiral 1,2,3-Triazoles Units and Precise Construction of Stereocontrolled Oligomers.Molecules (Basel, Switzerland) · 2023Article
- Synthesis of High Performance Thiophene-Aromatic Polyesters from Bio-Sourced Organic Acids and Polysaccharide-Derived Diol: Characterization and Degradability Studies.Molecules (Basel, Switzerland) · 2022Article
- Metabolic engineering strategy for synthetizing trans-4-hydroxy-L-proline in microorganisms.Microbial cell factories · 2021Review
- High-throughput preparation of radioprotective polymers via Hantzsch's reaction for in vivo X-ray damage determination.Nature communications · 2020Article
- A versatile strategy for the synthesis of sequence-defined peptoids with side-chain and backbone diversityChemical science · 2019Article
- Sequence-definition in stiff conjugated oligomers.Scientific reports · 2018Article
- Green Tea Catechin Dramatically Promotes RNAi Mediated by Low-Molecular-Weight Polymers.ACS central science · 2018Article
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8 authors.
Funding
Abstract
The functionality of natural biopolymers has inspired significant effort to develop sequence-defined synthetic polymers for applications including molecular recognition, self-assembly, and catalysis. Conjugation of synthetic materials to biomacromolecules has played an increasingly important role in drug delivery and biomaterials. We developed a controlled synthesis of novel oligomers from hydroxyproline-based building blocks and conjugated these materials to siRNA. Hydroxyproline-based monomers enable the incorporation of broad structural diversity into defined polymer chains. Using a perfluorocarbon purification handle, we were able to purify diverse oligomers through a single solid-phase extraction method. The efficiency of synthesis was demonstrated by building 14 unique trimers and 4 hexamers from 6 diverse building blocks. We then adapted this method to the parallel synthesis of hundreds of materials in 96-well plates. This strategy provides a platform for the screening of libraries of modified biomolecules.
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