Evidence map›Paper›PMID 27365163›Full record

ReviewTrends in endocrinology and metabolism: TEM2016

Regulation and Functions of Autophagic Lipolysis.

Francesca Cingolani, Mark J Czaja

Abstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Journal of fungi (Basel, Switzerland) · 2023
    Article
  16. The PNPLA family of enzymes: characterisation and biological role.Arhiv za higijenu rada i toksikologiju · 2023
    Article
  17. Review
  18. Article
  19. Important Hormones Regulating Lipid Metabolism.Molecules (Basel, Switzerland) · 2022
    Review
  20. Perilipin-2 limits remyelination by preventing lipid droplet degradation.Cellular and molecular life sciences : CMLS · 2022
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Francesca CingolaniDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine. 615 Michael Street, Suite 201, Atlanta, GA 30322, USA.
Mark J CzajaDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine. 615 Michael Street, Suite 201, Atlanta, GA 30322, USA. Electronic address: mark.j.czaja@emory.edu.

Funding

Role of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MACIAN, FERNANDO · 2009 to 2024
$36.2M
Role of CYP2E1 in the Progression to NASHR01DK061498 · NIDDK · YESHIVA UNIVERSITY · PI CZAJA, MARK J · 2002 to 2015
$4.7M
Regulation of the innate immune response in alcoholic liver disease by autophagyR01AA022601 · NIAAA · EMORY UNIVERSITY · PI CZAJA, MARK J · 2014 to 2018
$2.1M
NIAAA NIH HHS R01 AA022601NIA NIH HHS P01 AG031782NIDDK NIH HHS R01 DK061498
6 · The paper itself

Abstract

The selective breakdown by autophagy of lipid droplet (LD)-stored lipids, termed lipophagy, is a lysosomal lipolytic pathway that complements the actions of cytosolic neutral lipases. The physiological importance of lipophagy has been demonstrated in multiple mammalian cell types, as well as in lower organisms, and this pathway has many functions in addition to supplying free fatty acids to maintain cellular energy stores. Recent studies have begun to delineate the molecular mechanisms of the selective recognition of LDs by the autophagic machinery, as well as the intricate crosstalk between the different forms of autophagy and neutral lipases. These studies have led to increased interest in the role of lipophagy in both human disease pathogenesis and therapy.

Indexed as

AnimalsAutophagyHumansLipid DropletsLipid MetabolismLipolysisPerilipin-1Perilipin-1autophagylipid dropletlipophagylivermacrophageperilipin

Identifiers

PMID27365163
PMCPMC5035575

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.