ArticleLasers in medical science2016
Effects of combination of melatonin and laser irradiation on ovarian cancer cells and endothelial lineage viability.
Article in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- The effect of the debulking by excimer laser coronary angioplasty on long-term outcome compared with drug-coating balloon: insights from optical frequency domain imaging analysis.Lasers in medical science · 2020Trial
- Low-level laser irradiation stimulated tumoricidal impacts and dose-dependent modulation of Wnt signaling in three-dimensional human colorectal cancer microspheres.Lasers in medical science · 2026Article
- Melatonin Induces PERK-ATF4 Unfolded Protein Response and Apoptosis in Human Choriocarcinoma Cells.Journal of pineal research · 2025Article
- Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A Review of Current Evidence.Current drug targets · 2024Review
- Melatonin Reverses the Warburg-Type Metabolism and Reduces Mitochondrial Membrane Potential of Ovarian Cancer Cells Independent of MT1 Receptor Activation.Molecules (Basel, Switzerland) · 2022Article
- Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.Molecules (Basel, Switzerland) · 2021Review
- Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease.Journal of inflammation (London, England) · 2021Review
- Melatonin as a Radio-Sensitizer in Cancer.Biomedicines · 2020Review
- Low-Level Laser Irradiation Modulated Viability of Normal and Tumor Human Lymphocytes In Vitro.Journal of lasers in medical sciences · 2020Article
- Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line.Current pharmaceutical biotechnology · 2020Article
- Melatonin is a potential inhibitor of ovarian cancer: molecular aspects.Journal of ovarian research · 2019Review
- Photo-modulation of zinc phthalocyanine-treated breast cancer cell line ZR-75-1 inhibited the normal tumor activity in vitro.Lasers in medical science · 2018Article
- Low-level laser irradiation at a high power intensity increased human endothelial cell exosome secretion via Wnt signaling.Lasers in medical science · 2018Article
- Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers.International journal of endocrinology · 2018Review
- Radiosensitivity of human ovarian cancer cells is enhanced by pseudolaric acid B due to the inhibition of the Ras/Raf/ERK signaling pathway.Experimental and therapeutic medicine · 2018Article
- Evaluation of cell death pathways initiated by antitumor drugs melatonin and valproic acid in bladder cancer cells.FEBS open bio · 2017Article
- Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress.Molecules (Basel, Switzerland) · 2016Review
- The Impact of Nrf2 Silencing on Nrf2-PD-L1 Axis to Overcome Oxaliplatin Resistance and Migration in Colon Cancer Cells.Avicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main goal of anti-cancer therapeutic approaches is to induce apoptosis in tumor masses but not in the normal tissues. Nevertheless, the combination of photodynamic irradiation with complementary oncostatic agents contributes to better therapeutic performance. Here, we applied two different cell lines; SKOV3 ovarian carcinoma cells and HUVECs umbilical cord cells as in vitro models to pinpoint whether pharmacological concentration of melatonin in combination with photodynamic therapy induces cell cytotoxicity. The cells were separately treated with various concentrations of melatonin (0 to 10 mM) and photodynamic irradiation alone or in combination. Cells were preliminary exposed to increasing concentrations of melatonin for 24 h and subsequently underwent laser irradiation for 60 s with an output power of 80 mW in continuous mode at 675 nm wavelength and a total light dose of 13.22 J/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.