Evidence map›Paper›PMID 27365041›Full record

ReviewEssays in biochemistry2016

Lateral flow assays.

Katarzyna M Koczula, Andrea Gallotta

Registry-linked trialAbstract readReview
In one paragraph

Review in Essays in biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05476822 (Profiling Spike Protein Antibody Response Post COVID-19 Booster), which is not on this map. Cited by 461 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
461citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05476822 withdrawnnot on this mapstarted 2022, after this paper: background citation

Profiling Spike Protein Antibody Response Post COVID-19 Booster

TypeobservationalSponsorDavid Grant U.S. Air Force Medical CenterRan2022 to 2023Enrolled0ConditionsCOVID-19 Booster, Spike Protein IgG AntibodyArmsObtain antibody titers
3 · Its place in the literature

Who cites it

461 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Independent Testing to Accelerate the Development of Lateral Flow Assays for Influenza A, Influenza B and SARS-COV-2.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
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401 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katarzyna M KoczulaXeptagen SpA, VEGA Science Park, Via delle Industrie 9, Venice, Italy.
Andrea GallottaXeptagen SpA, VEGA Science Park, Via delle Industrie 9, Venice, Italy gallotta@xeptagen.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lateral flow assays (LFAs) are the technology behind low-cost, simple, rapid and portable detection devices popular in biomedicine, agriculture, food and environmental sciences. This review presents an overview of the principle of the method and the critical components of the assay, focusing on lateral flow immunoassays. This type of assay has recently attracted considerable interest because of its potential to provide instantaneous diagnosis directly to patients. The range and interpretation of results and parameters used for evaluation of the assay will also be discussed. The main advantages and disadvantages of LFAs will be summarized and relevant future improvements to testing devices and strategies will be proposed. Finally, the major recent advances and future diagnostic applications in the LFA field will be explored.

Indexed as

Capillary ActionBiosensing TechniquesImmunoassayMembranes, ArtificialMolecular Diagnostic TechniquesMembranes, Artificialcapillary flowlateral flow assay (LFA)nitrocellulose membranepoint-of-carepregnancy test

Identifiers

PMID27365041
PMCPMC4986465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.