Evidence map›Paper›PMID 27365032›Full record

ReviewEssays in biochemistry2016

Non-antibody protein-based biosensors.

Paul Ko Ferrigno

Abstract readReview
In one paragraph

Review in Essays in biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Duplex On-Site Detection ofBiosensors · 2021
    Article
  8. Review
  9. Article
  10. Review
  11. Optical Fiber Gratings Immunoassays.Sensors (Basel, Switzerland) · 2019
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul Ko FerrignoAvacta Life Sciences Ltd., Unit 651A, Street 5, Thorp Arch Estate, Wetherby LS23 7FZ, U.K. paul.koferrigno@avacta.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosensors that depend on a physical or chemical measurement can be adversely affected by non-specific interactions. For example, a biosensor designed to measure specifically the levels of a rare analyte can give false positive results if there is even a small amount of interaction with a highly abundant but irrelevant molecule. To overcome this limitation, the biosensor community has frequently turned to antibody molecules as recognition elements because they are renowned for their exquisite specificity. Unfortunately antibodies can often fail when immobilised on inorganic surfaces, and alternative biological recognition elements are needed. This article reviews the available non-antibody-binding proteins that have been successfully used in electrical and micro-mechanical biosensor platforms.

Indexed as

Aptamers, PeptideBiosensing TechniquesProtein BindingRecombinant Fusion ProteinsAptamers, PeptideRecombinant Fusion ProteinsadhironsAffimersAnticalinsaptamersDarpinsnanobodies

Identifiers

PMID27365032
PMCPMC4986471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.