ArticleScientific reports2016
The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
175 citing papers in PubMed, 2 syntheses or guidelines pooled it, 333 citations in OpenAlex.
- Transovarial transmission of mosquito-borne viruses: a systematic review.Frontiers in cellular and infection microbiology · 2023Pooled it
- Zika virus: An updated review of competent or naturally infected mosquitoes.PLoS neglected tropical diseases · 2017Pooled it
- Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue.The New England journal of medicine · 2021Trial
- Wolbachia prevalence in Aedes aegypti across five comunas of Medellín, Colombia: Implications for post-release surveillance.PLoS neglected tropical diseases · 2026Article
- Detection of supergroup B Wolbachia strains and their co-infection with Plasmodium falciparum in wild Anopheles funestus in southeastern Tanzania: implications for malaria control.Parasites & vectors · 2026Article
- Ecological vaccination: A strategy to prevent zoonotic spillover from bats.Science advances · 2026Article
- The impact of large-scale release ofLancet regional health. Americas · 2026Article
- Review
- Horizons of the Future: Preparedness and Response.Current topics in microbiology and immunology · 2026Review
- Wolbachia introgression in Rio de Janeiro remains at sub-optimal levels 30 months after its decline: challenges in the sustainability of wMel interventions for dengue control.Memorias do Instituto Oswaldo Cruz · 2026Article
- Molecular Identification and Phylogeny of NaturalJournal of tropical medicine · 2026Article
- Long-Term Durability and Public Health Impact of City-WideTropical medicine and infectious disease · 2025Article
- Citrus aurantium L. and Citrus latifolia extracts as alternative control agents for Aedes aegypti (Diptera: Culicidae).Biological research · 2025Article
- Molecular Survey and Genetic Identification of Wolbachia Endosymbionts in Dwelling-Caught Culex quinquefasciatus (Diptera: Culicidae) Mosquitoes from Taiwan.Microbial ecology · 2025Article
- Wolbachia Offers Protection Against Two Common Natural Viruses of Drosophila.Microbial ecology · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Review
- Wolbachia incompatible insect technique program optimization over large spatial scales using a process-based model of mosquito metapopulation dynamics.BMC biology · 2024Article
- Variable effects of transient Wolbachia infections on alphaviruses in Aedes aegypti.PLoS neglected tropical diseases · 2024Article
- The dynamics of the midgut microbiome inPNAS nexus · 2024Article
115 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Zika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this virus, and mosquito control strategies have not been adequate to contain the virus. A promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium Wolbachia into Aedes aegypti mosquitoes. This primarily has been proposed as a tool to control dengue virus (DENV) transmission; however, evidence suggests Wolbachia infections confer protection for Ae. aegypti against other arboviruses. At present, it is unknown whether or not ZIKV can infect, disseminate, and be transmitted by Wolbachia-infected Ae. aegypti. Using Ae. aegypti infected with the wMel strain of Wolbachia that are being released in Medellin, Colombia, we report that these mosquitoes have reduced vector competence for ZIKV. These results support the use of Wolbachia biocontrol as a multivalent strategy against Ae. aegypti-transmitted viruses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.