Evidence map›Paper›PMID 27364631›Full record

ArticleMagnetic resonance in medicine2017

Chemical exchange saturation transfer (CEST) imaging with fast variably-accelerated sensitivity encoding (vSENSE).

Yi Zhang, Hye-Young Heo, Dong-Hoon Lee, Shanshan Jiang, Xuna Zhao, Paul A Bottomley, Jinyuan Zhou

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
  2. Article
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  7. Review
  8. CEST MRI trackable nanoparticle drug delivery systems.Biomedical materials (Bristol, England) · 2021
    Review
  9. Review
  10. Article
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  12. Review
  13. Article
  14. Article
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  16. Fast, Reliable 3D Amide Proton Transfer Imaging of Brain Tumors at 3T with Variably-accelerated Sensitivity Encoding (vSENSE).Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition · 2017
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi ZhangDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-8738-1851
Hye-Young HeoDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Dong-Hoon LeeDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Shanshan JiangDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Xuna ZhaoDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Paul A BottomleyDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Jinyuan ZhouDivision of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

Advanced MRI Technology in Safety & InterventionR01EB007829 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BOTTOMLEY, PAUL A · 2008 to 2017
$4.3M
Amide Proton Transfer (APT) MRI of Brain Tumors at 3T and 7TR01EB009731 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2009 to 2016
$2.9M
Academic-Industrial Partnership to Develop Clinical Brain Cancer ImagingR01CA166171 · NCI · JOHNS HOPKINS UNIVERSITY · PI VAN ZIJL, PETER CM, ZHOU, JINYUAN · 2013 to 2017
$2.4M
US-China Collaborative Research on Stroke ImagingR01NS083435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2013 to 2015
$588k
Molecular MRI of Radiation Necrosis in Preclinical ModelsR21EB015555 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2012 to 2013
$447k
NCI NIH HHS R01 CA166171NIBIB NIH HHS R01 EB007829NIBIB NIH HHS R01 EB009731NIBIB NIH HHS R21 EB015555NINDS NIH HHS R01 NS083435
6 · The paper itself

Abstract

purposeThe widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered by relatively long scan times due to its requirement that multiple saturation-offset image frames be acquired. Here, a novel variably-accelerated sensitivity encoding (vSENSE) method is proposed that provides faster CEST acquisition than conventional SENSE. THEORY AND

methodsThe vSENSE method fully samples one CEST saturation frame, then undersamples the other frames variably. The fully-sampled frame, in conjunction with newly proposed incoherence absorption and artifact suppression strategies, improves the accuracy of sensitivity maps and permits higher acceleration factors for the other undersampled frames than regular SENSE. vSENSE is validated in a phantom, a normal volunteer and eight brain tumor patients at 3 Tesla.

resultsvSENSE with an acceleration factor of four generated a 3-6 times smaller error on average than conventional SENSE (P ≤ 0.02), with acceleration factors of 2-4, as compared with full k-space reconstruction. vSENSE permitted four-fold acceleration for amide proton transfer-weighted images, while regular SENSE could only provide a factor of two. When conventional SENSE is used with vSENSE's variable undersampling pattern, erroneous (∼9%) z-spectra result.

conclusionThe vSENSE method enabled twice the acceleration and generated more accurate images than conventional SENSE. Magn Reson Med 77:2225-2238, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

Signal Processing, Computer-AssistedAlgorithmsBrain NeoplasmsHumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMolecular ImagingPhantoms, ImagingReproducibility of ResultsSensitivity and Specificityamide proton transfer (APT)brain tumorchemical exchange saturation transfer (CEST)sensitivity encoding (SENSE)variably-accelerated sensitivity encoding (vSENSE)

Identifiers

PMID27364631
PMCPMC5213670

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.