ReviewWorld journal of urology2017
The rationale and the role of lymph node dissection in renal cell carcinoma.
Review in World journal of urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07321197 (Template Lymph Node Dissection for Tumor Control in High-Risk Renal Cell Carcinoma), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Template Lymph Node Dissection for Tumor Control in High-Risk Renal Cell Carcinoma: A Prospective, Open-Label, Multicenter, Randomized Controlled Trial
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Clinical outcomes and prognostic factors in patients undergoing radical nephrectomy with lymphadenectomy for pN1 renal cell carcinoma.BMC urology · 2025Article
- Article
- A Novel Predictive Model of Pathological Lymph Node Metastasis Constructed with Preoperative Independent Predictors in Patients with Renal Cell Carcinoma.Journal of clinical medicine · 2023Article
- Potential benefit of lymph node dissection during radical nephrectomy for kidney cancer: A review and critical analysis of current literature.Asian journal of urology · 2022Review
- Contemporary techniques and outcomes of surgery for locally advanced renal cell carcinoma with focus on inferior vena cava thrombectomy: The value of a multidisciplinary team.Asian journal of urology · 2022Article
- Risk Factors and Patterns of Locoregional Recurrence after Radical Nephrectomy for Locally Advanced Renal Cell Carcinoma.Cancer research and treatment · 2022Article
- The role of 18F-FAZA PET/CT in detecting lymph node metastases in renal cell carcinoma patients: a prospective pilot trial.European journal of nuclear medicine and molecular imaging · 2021Article
- Dissecting the role of lymphadenectomy in the management of renal cell carcinoma: past, present, and future.Kidney cancer journal : official journal of the Kidney Cancer Association · 2020Article
- Valuation of lymph node dissection in localized high-risk renal cell cancer using X-tile software.International urology and nephrology · 2020Article
- Accuracy of clinical nodal staging and factors associated with receipt of lymph node dissection at the time of surgery for nonmetastatic renal cell carcinoma.Urologic oncology · 2019Article
- The side and the location of the primary tumor does not affect the probability of lymph node invasion in patients with renal cell carcinoma.World journal of urology · 2019Article
- Predictive and prognostic effect of inflammatory lymphadenopathies in renal cell carcinoma.World journal of urology · 2019Article
- Radical Nephrectomy with or without Lymph Node Dissection for pT3 Renal Cell Carcinoma: A Propensity Score-based Analysis.Journal of Cancer · 2019Article
- A Novel Preoperative Nomogram for Predicting Lymph Node Invasion in Renal Cell Carcinoma Patients Without Metastasis.Cancer management and research · 2019Article
- Epidemiology, biology and treatment of sarcomatoid RCC: current state of the art.World journal of urology · 2019Review
- The contemporary role of lymph node dissection in the management of renal cell carcinoma.Therapeutic advances in urology · 2018Review
- Pathologic Predictors of Survival During Lymph Node Dissection for Metastatic Renal-Cell Carcinoma: Results From a Multicenter Collaboration.Clinical genitourinary cancer · 2018Article
- The Effect of Anatomical Location of Lymph Node Metastases on Cancer Specific Survival in Patients with Clear Cell Renal Cell Carcinoma.Frontiers in surgery · 2018Article
- Templates of Lymph Node Dissection for Renal Cell Carcinoma: A Systematic Review of the Literature.Frontiers in surgery · 2018Article
- Lymph node dissection in urological cancers: one topic, many controversies.World journal of urology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough the role of lymph node dissection (LND) is well defined in many urological settings, uncertainty regarding need for LND still exists for patients with renal cell carcinoma (RCC). The aim of the current review is to highlight the rationale for performing or omitting LND at the time of renal surgery.
methodsData were identified through a search of PubMed and Web of Science, including studies published in the last 20 years in core clinical journals. The review is based on evidence synthesis from a peer-review process of the two authors after a structured data search.
resultsNeither imaging, nor predictive tools or molecular/genetic markers accurately identify which patients may warrant a LND. In patients with clinical T1abN0 and absence of unfavorable clinical and pathological characteristics, LND does not appear to offer benefit in terms of staging and cancer control. Conversely, LND can be considered in selected cases (larger tumors, locally advanced diseases or when unfavorable pathological characteristics are likely, as high Fuhrman grade, sarcomatoid features or tumor necrosis) due to the non-negligible risk of associated nodal metastases and possible benefit in terms of cancer control.
conclusionsAlthough LND does not provide any benefit in the majority of RCC cases (mainly T1abN0M0 cases), it remains an important consideration in intermediate-/high-risk patients for staging purposes, given an increased risk of LNI, and for potential benefit in terms of cancer control. Additional data are urgently needed to improve the accuracy of nodal staging tools and to evaluate the potential role of salvage LND.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.