ArticleMicrobiome2016
Nasopharyngeal microbiota composition of children is related to the frequency of upper respiratory infection and acute sinusitis.
Article in Microbiome, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Nasal microbiome and phageome profiles are associated with prospective respiratory viral infection risk in school-age children.The Journal of allergy and clinical immunology · 2026Article
- Perinatal exposures and upper respiratory tract microbiome composition are associated with age at first acute otitis media episode.bioRxiv : the preprint server for biology · 2026Article
- Article
- Characteristics of the microbiota in the nasopharynx and nasal cavity of healthy children before and during the COVID-19 pandemic.World journal of pediatrics : WJP · 2025Article
- Big lessons from the littleFrontiers in immunology · 2025Review
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Identifying the Microbiome of the Adenoid Surface of Children Suffering from Otitis Media with Effusion and Children without Middle Ear Effusion Using 16S rRNA Genetic Sequencing.Microorganisms · 2023Article
- Enrichment of human nasopharyngeal bacteriome with bacteria from dust after short-term exposure to indoor environment: a pilot study.BMC microbiology · 2023Article
- Microbiome in Nasal Mucosa of Children and Adolescents with Allergic Rhinitis: A Systematic Review.Children (Basel, Switzerland) · 2023Review
- Differences in the effects ofFrontiers in pediatrics · 2023Article
- Nasopharyngeal microbiota profiling of pregnant women with SARS-CoV-2 infection.Scientific reports · 2022Article
- Progressive deterioration of the upper respiratory tract and the gut microbiomes in children during the early infection stages of COVID-19.Journal of genetics and genomics = Yi chuan xue bao · 2021Article
- The microbiome of the nasopharynx.Journal of medical microbiology · 2021Review
- Oropharyngeal Probiotic ENT-K12 Prevents Respiratory Tract Infections Among Frontline Medical Staff Fighting Against COVID-19: A Pilot Study.Frontiers in bioengineering and biotechnology · 2021Article
- Moraxella-dominated pediatric nasopharyngeal microbiota associate with upper respiratory infection and sinusitis.PloS one · 2021Article
- Article
- Commensal bacteria in the upper respiratory tract regulate susceptibility to infection.Current opinion in immunology · 2020Review
- Effects of long-distance transportation on blood constituents and composition of the nasal microbiota in healthy donkeys.BMC veterinary research · 2020Article
- Comparison of the human microbiome in adults and children with chronic rhinosinusitis.PloS one · 2020Article
- 16S Metagenomics Reveals Dysbiosis of Nasal Core Microbiota in Children With Chronic Nasal Inflammation: Role of Adenoid Hypertrophy and Allergic Rhinitis.Frontiers in cellular and infection microbiology · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundUpper respiratory infections (URI) and their complications are a major healthcare burden for pediatric populations. Although the microbiology of the nasopharynx is an important determinant of the complications of URI, little is known of the nasopharyngeal (NP) microbiota of children, the factors that affect its composition, and its precise relationship with URI.
resultsHealthy children (n = 47) aged 49-84 months from a prospective cohort study based in Wisconsin, USA, were examined. Demographic and clinical data and NP swab samples were obtained from participants upon entry to the study. All NP samples were profiled for bacterial microbiota using a phylogenetic microarray, and these data were related to demographic characteristics and upper respiratory health outcomes. The composition of the NP bacterial community of children was significantly related prior to the history of acute sinusitis (R (2) = 0.070, P < 0.009). History of acute sinusitis was associated with significant depletion in relative abundance of taxa including Faecalibacterium prausnitzii and Akkermansia spp. and enrichment of Moraxella nonliquefaciens. Enrichment of M. nonliquefaciens was also a characteristic of baseline NP samples of children who subsequently developed acute sinusitis over the 1-year study period. Time to develop URI was significantly positively correlated with NP diversity, and children who experienced more frequent URIs exhibited significantly diminished NP microbiota diversity (P ≤ 0.05).
conclusionsThese preliminary data suggest that previous history of acute sinusitis influences the composition of the NP microbiota, characterized by a depletion in relative abundance of specific taxa. Diminished diversity was associated with more frequent URIs.
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