ArticleScientific reports2016
Ultrasensitive multiplex optical quantification of bacteria in large samples of biofluids.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 65 citations in OpenAlex.
- Gold- or Silver-Nanoparticle SERS Platforms for Plasma-Based Diagnostics and AI-Driven Analysis.Sensors (Basel, Switzerland) · 2026Review
- Recent advances in microfluidic-based spectroscopic approaches for pathogen detection.Biomicrofluidics · 2024Review
- Challenges and perspectives of multi-virus biosensing techniques: A review.Analytica chimica acta · 2023Review
- Evaluation of a Luminometric Cell Counting System in Context of Antimicrobial Photodynamic Inactivation.Microorganisms · 2022Article
- Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells.Science China. Life sciences · 2022Article
- Micro- and nanosensors for detecting blood pathogens and biomarkers at different points of sepsis care.Mikrochimica acta · 2022Review
- Positively-charged plasmonic nanostructures for SERS sensing applications.RSC advances · 2021Review
- Surface enhanced Raman scattering for the multiplexed detection of pathogenic microorganisms: towards point-of-use applications.The Analyst · 2021Review
- Review
- Review on Recent Progress in Magnetic Nanoparticles: Synthesis, Characterization, and Diverse Applications.Frontiers in chemistry · 2021Review
- Magnetically Enhanced Liquid SERS for Ultrasensitive Analysis of Bacterial and SARS-CoV-2 Biomarkers.Frontiers in bioengineering and biotechnology · 2021Article
- Surface-enhanced Raman scattering holography.Nature nanotechnology · 2020Article
- Bacteria Detection: From Powerful SERS to Its Advanced Compatible Techniques.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Present and Future of Surface-Enhanced Raman Scattering.ACS nano · 2020Article
- Modular assembly of plasmonic core-satellite structures as highly brilliant SERS-encoded nanoparticles.Nanoscale advances · 2019Article
- Applications of Iron Oxide-Based Magnetic Nanoparticles in the Diagnosis and Treatment of Bacterial Infections.Frontiers in bioengineering and biotechnology · 2019Review
- Surface Modifications of Nanoparticles for Stability in Biological Fluids.Materials (Basel, Switzerland) · 2018Review
- Optofluidic device for the quantification of circulating tumor cells in breast cancer.Scientific reports · 2017Article
- Optimization of Nanoparticle-Based SERS Substrates through Large-Scale Realistic Simulations.ACS photonics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficient treatments in bacterial infections require the fast and accurate recognition of pathogens, with concentrations as low as one per milliliter in the case of septicemia. Detecting and quantifying bacteria in such low concentrations is challenging and typically demands cultures of large samples of blood (~1 milliliter) extending over 24-72 hours. This delay seriously compromises the health of patients. Here we demonstrate a fast microorganism optical detection system for the exhaustive identification and quantification of pathogens in volumes of biofluids with clinical relevance (~1 milliliter) in minutes. We drive each type of bacteria to accumulate antibody functionalized SERS-labelled silver nanoparticles. Particle aggregation on the bacteria membranes renders dense arrays of inter-particle gaps in which the Raman signal is exponentially amplified by several orders of magnitude relative to the dispersed particles. This enables a multiplex identification of the microorganisms through the molecule-specific spectral fingerprints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.