Evidence map›Paper›PMID 27363816›Full record

ArticleBMJ open2016

Submaximal fitness and mortality risk reduction in coronary heart disease: a retrospective cohort study of community-based exercise rehabilitation.

Claire Taylor, Costas Tsakirides, James Moxon, James William Moxon, Michael Dudfield, Klaus K Witte, Lee Ingle, Sean Carroll

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Claire TaylorDepartment of Sport, Health and Exercise Science, University of Hull, Hull, UK.
Costas TsakiridesCarnegie School of Sport, Leeds Beckett University, Leeds, UK.
James MoxonBurton Croft Surgery, Leeds, UK.
James William MoxonRetired General Practitioner, Leeds, UK.
Michael DudfieldRetired Fitness Development Officer, Sports Development, Leeds Leisure Services, Leeds, UK.
Klaus K WitteDivision of Cardiovascular and Diabetes Research, University of Leeds, Leeds, UK.
Lee IngleDepartment of Sport, Health and Exercise Science, University of Hull, Hull, UK.
Sean CarrollDepartment of Sport, Health and Exercise Science, University of Hull, Hull, UK.
University of Hull · GBRoyal College of General Practitioners · GBLeeds Beckett University · GBUniversity of Leeds · GB

Funding

Department of Health NIHR-CS-012-032
6 · The paper itself

Abstract

objectivesTo examine the association between submaximal cardiorespiratory fitness (sCRF) and all-cause mortality in a cardiac rehabilitation (CR) cohort.

designRetrospective cohort study of participants entering CR between 26 May 1993 and 16 October 2006, followed up to 1 November 2013 (median 14 years, range 1.2-19.4 years).

settingA community-based CR exercise programme in Leeds, West Yorkshire, UK.

participantsA cohort of 534 men (76%) and 136 women with a clinical diagnosis of coronary heart disease (CHD), aged 22-82 years, attending CR were evaluated for the association between baseline sCRF and all-cause mortality. 416 participants with an exercise test following CR (median 14 weeks) were examined for changes in sCRF and all-cause mortality.

main outcome measuresAll-cause mortality and change in sCRF expressed in estimated metabolic equivalents (METs).

resultsBaseline sCRF was a strong predictor of all-cause mortality; compared to the lowest sCRF group (<5 METs for women and <6 METs for men), mortality risk was 41% lower in those with moderate sCRF (HR 0.59; 95% CI 0.42 to 0.83) and 60% lower (HR 0.40; 95% CI 0.25 to 0.64) in those with higher sCRF levels (≥7 METs women and ≥8 METs for men). Although improvement in sCRF at 14 weeks was not associated with a significant mortality risk reduction (HR 0.91; 95% CI 0.79 to 1.06) for the whole cohort, in those with the lowest sCRF (and highest all-cause mortality) at baseline, each 1-MET improvement was associated with a 27% age-adjusted reduction in mortality risk (HR 0.73; 95% CI 0.57 to 0.94).

conclusionsHigher baseline sCRF is associated with a reduced risk of all-cause mortality over 14 years in adults with CHD. Improving fitness through exercise-based CR is associated with significant risk reduction for the least fit.

Indexed as

Cardiorespiratory FitnessExercise TherapyRisk Reduction BehaviorAdultAgedAged, 80 and overCause of DeathCoronary DiseaseFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesYoung Adultcardiac rehabilitationcardiorespiratory fitnessCHDsubmaximal exercise testingsurvival

Identifiers

PMID27363816
PMCPMC4932274
OpenAlexW2474134187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.