ArticleScientific reports2016
Effects of neonatal stress on gamma oscillations in hippocampus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Molecular and neural circuit mechanisms of parvalbumin (PV) neurons in depression: Insights and advances.iScience · 2026Review
- Screening system for assessing suitability of cognitive behavioral therapy for chronic low back pain.Scientific reports · 2025Article
- Influence of early-life stress on hippocampal synaptic and network properties.Frontiers in neural circuits · 2024Review
- Gamma-band entrainment abnormalities in schizophrenia: Modality-specific or cortex-wide impairment?Journal of psychopathology and clinical science · 2022Article
- Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review.Neurobiology of stress · 2021Review
- Naringin Confers Protection against Psychosocial Defeat Stress-Induced Neurobehavioral Deficits in Mice: Involvement of Glutamic Acid Decarboxylase Isoform-67, Oxido-Nitrergic Stress, and Neuroinflammatory Mechanisms.Journal of molecular neuroscience : MN · 2021Article
- Adverse caregiving in infancy blunts neural processing of the mother.Nature communications · 2020Article
- Review
- Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods.Neurobiology of learning and memory · 2017Review
- Electron Microscopic Analysis of Hippocampal Axo-Somatic Synapses in a Chronic Stress Model for Depression.Hippocampus · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic early life stress increases adult risk for depression, bipolar disorder and schizophrenia, illnesses characterized by aberrant functions of cognition and memory. We asked whether chronic early life stress disrupts maturation of gamma oscillations, on which these functions depend. Lifelong impairment of the stress response results from separation of rat pups from the dam for three hours per day during a critical period of hippocampal development (PNDs 2-14). Parvalbumin-expressing interneurons, including the basket cell network which is fundamental to gamma oscillations, are reduced in number in post mortem studies of bipolar disorder and schizophrenia, and in chronically-stressed adult rats. To determine effects of chronic early life stress on gamma oscillations, we separated pups from dams once each day on PNDs 2-14 and recorded in vitro at PNDs 15-21. In control pups, separated for 15 minutes per day, gamma power had highly significant correlations with both age (p = 0.0022) and weight (p = 0.0024); gamma in pups separated for 180 minutes per day was not correlated with either factor. ANCOVA indicated significant differences between the groups in both measures. These findings indicate that chronic early life stress can disrupt maturation of the gamma oscillation network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.