Evidence map›Paper›PMID 27363516›Full record

ArticleScientific reports2016

The metabolome of [2-(14)C](-)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives.

Javier I Ottaviani, Gina Borges, Tony Y Momma, Jeremy P E Spencer, Carl L Keen, Alan Crozier, Hagen Schroeter

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06086145 (Flavanol Intake in Davis), which is not on this map. Cited by 89 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 4 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06086145 active not recruitingnot on this mapstarted 2023, after this paper: background citation

Flavanol Intake in Davis (FID) Study: Biomarker-estimated Habitual (-)-Epicatechin and Flavanol Intake in Adults

TypeobservationalSponsorUniversity of California, DavisRan2023 to 2026Enrolled200ConditionsHealthy, Diet, AdultsArmsNo intervention
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 4 syntheses or guidelines pooled it, 249 citations in OpenAlex.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Javier I OttavianiMars, Inc., McLean, VA 22101, USA.
Gina BorgesDepartment of Nutrition, University of California Davis, Davis, CA 95616, USA.
Tony Y MommaDepartment of Nutrition, University of California Davis, Davis, CA 95616, USA.
Jeremy P E SpencerDepartment of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6AP, UK.
Carl L KeenDepartment of Nutrition, University of California Davis, Davis, CA 95616, USA.
Alan CrozierDepartment of Nutrition, University of California Davis, Davis, CA 95616, USA.
Hagen SchroeterMars, Inc., McLean, VA 22101, USA.
University of California, Davis · USMars (United States) · USUniversity of Reading · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet is a major life style factor affecting human health, thus emphasizing the need for evidence-based dietary guidelines for primary disease prevention. While current recommendations promote intake of fruit and vegetables, we have limited understanding of plant-derived bioactive food constituents other than those representing the small number of essential nutrients and minerals. This limited understanding can be attributed to some extent to a lack of fundamental data describing the absorption, distribution, metabolism and excretion (ADME) of bioactive compounds. Consequently, we selected the flavanol (-)-epicatechin (EC) as an example of a widely studied bioactive food constituent and investigated the ADME of [2-(14)C](-)-epicatechin (300 μCi, 60 mg) in humans (n = 8). We demonstrated that 82 ± 5% of ingested EC was absorbed. We also established pharmacokinetic profiles and identified and quantified >20 different metabolites. The gut microbiome proved to be a key driver of EC metabolism. Furthermore, we noted striking species-dependent differences in the metabolism of EC, an insight with significant consequences for investigating the mechanisms of action underlying the beneficial effects of EC. These differences need to be considered when assessing the safety of EC intake in humans. We also identified a potential biomarker for the objective assessment of EC intake that could help to strengthen epidemiological investigations.

Indexed as

Administration, OralAdultAnimalsCarbon RadioisotopesCatechinChromatography, High Pressure LiquidDietary SupplementsHalf-LifeHumansMaleMass SpectrometryMiceMice, Inbred C57BLPolyphenolsRats, Sprague-DawleyStereoisomerismCarbon-14Carbon RadioisotopesCatechinPolyphenols

Identifiers

PMID27363516
PMCPMC4929566
OpenAlexW2464063195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.