Evidence map›Paper›PMID 27363424›Full record

Trial reportIrish journal of medical science2017

Influence of a CYP1A2 polymorphism on post-exercise heart rate variability in response to caffeine intake: a double-blind, placebo-controlled trial.

R M Thomas, H A Algrain, E J Ryan, A Popojas, P Carrigan, A Abdulrahman, A E Carrillo

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Irish journal of medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  5. TheNutrients · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

R M ThomasDepartment of Biology, Chatham University, Pittsburgh, PA, USA.
H A AlgrainDepartment of Biology, Chatham University, Pittsburgh, PA, USA.
E J RyanDepartment of Exercise Science, Chatham University, Pittsburgh, PA, USA.
A PopojasDepartment of Biology, Chatham University, Pittsburgh, PA, USA.
P CarriganDepartment of Biology, Chatham University, Pittsburgh, PA, USA.
A AbdulrahmanDepartment of Biology, Chatham University, Pittsburgh, PA, USA.
A E CarrilloDepartment of Exercise Science, Chatham University, Pittsburgh, PA, USA. acarrillo@chatham.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProposed differences in caffeine metabolism due to the CYP1A2*1F polymorphism have been linked to variations in cardiovascular disease risk.

aimsWe examined the influence of a CYP1A2*1F polymorphism on post-exercise heart rate variability (HRV) in response to caffeine intake.

methodsVolunteers were identified as A/A homozygotes (A/A; 4 females and 7 males; age: 25.3 ± 4.1 years; BMI: 25.9 ± 4.4 kg/m

resultsNo significant group differences were detected in HRV indices at BASE, POST1, or POST2 during both trials (p > 0.05). Rate of recovery (POST2-POST1) for the square root of the mean of squared differences between successive RR intervals (RMSSD) was significantly different between A/A (6.0 ± 2.5 ms) and C allele (3.6 ± 2.5 ms) groups during the CAF trial (p = 0.048).

conclusionsRate of RMSSD recovery was the only variable influenced by the CYP1A2*IF polymorphism during post-exercise in response to caffeine intake. Thus, the CYP1A2*1F polymorphism did not overtly influence the effects of caffeine intake on post-exercise HRV.

Indexed as

AdultAllelesCaffeineCytochrome P-450 CYP1A2Double-Blind MethodExerciseFemaleHeart RateHeterozygoteHomozygoteHumansMaleMiddle AgedPolymorphism, GeneticYoung AdultCaffeineCYP1A2 protein, humanCytochrome P-450 CYP1A2Autonomic nervous systemCardiovascular abnormalitiesCytochrome p 450 CYP1A2Parasympathetic nervous systemPhysical activitySympathetic nervous system

Identifiers

PMID27363424

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.