Evidence map›Paper›PMID 27363402›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2016

Squamous cell carcinoma of unknown primary tumor metastatic to neck nodes: role of elective irradiation.

Primož Strojan, Marko Kokalj, Vesna Zadnik, Aleksandar Aničin, Gaber Plavc, Vojislav Didanović, Robert Šifrer, Boštjan Lanišnik

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06578871 (Surgery for the Unknown Primary in the Era of p16-positive Oropharyngeal Squamous Cell Carcinoma), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06578871 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Surgery for the Unknown Primary in the Era of p16-positive Oropharyngeal Squamous Cell Carcinoma: Reducing Ionizing Radiation (SUPERIOR): A Randomized Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2025 to 2027Enrolled90ConditionsHead and Neck Squamous Cell Carcinoma, HPV Positive Oropharyngeal Squamous Cell CarcinomaArmsIntensity Modulated Radiotherapy (IMRT) to Mucosa at Risk, Surgical Intervention, Intensity Modulated Radiotherapy (IMRT) to Ipsilateral Neck
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Primož StrojanDepartment of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000, Ljubljana, Slovenia. pstrojan@onko-i.si.
Marko KokaljDepartment of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000, Ljubljana, Slovenia.
Vesna ZadnikEpidemiology and Cancer Registries, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Aleksandar AničinUniversity Department of Otorhinolaryngology and Cervicofacial Surgery, University Clinical Center Ljubljana, Ljubljana, Slovenia.
Gaber PlavcDepartment of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000, Ljubljana, Slovenia.
Vojislav DidanovićDepartment of Maxillofacial and Oral Surgery, University Clinical Center Ljubljana, Ljubljana, Slovenia.
Robert ŠifrerUniversity Department of Otorhinolaryngology and Cervicofacial Surgery, University Clinical Center Ljubljana, Ljubljana, Slovenia.
Boštjan LanišnikDepartment of Otorhinolaryngology, Cervical and Maxillofacial Surgery, University Clinical Center Maribor, Maribor, Slovenia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with squamous cell carcinoma (SCC) metastases to neck lymph nodes and unknown primary tumor, the role of elective irradiation of uninvolved neck and potential mucosal primary sites is yet to be determined. The aim of this study was to review the experience treating SCC of unknown primary metastatic to neck nodes with surgery and postoperative radiotherapy (PORT) in Slovenia between 1995 and 2010 and to determine the importance of the extent of irradiated volume. For this purpose, the nationwide Cancer Registry of Slovenia database was used for identifying patients. 126 patients were identified. Involved-field PORT and extended-field PORT was used in 50 and 76 patients, respectively. At 5 years, locoregional control was 86 %, disease-specific survival 77 %, and overall survival 57 %. In multivariate analysis, the extent of irradiated volume has not been predictive for any outcome under study. Grade ≥3 acute and late radiotherapy-induced toxicities were more frequent in the extended-field PORT group. In conclusion, although not superior, involved-field PORT seems to be a preferred treatment option in SCC of unknown primary metastatic to neck nodes due to significantly reduced toxicity and better prospects for successful salvage.

Indexed as

AdultAgedAged, 80 and overAge FactorsCarcinoma, Squamous CellDose Fractionation, RadiationFemaleHumansLymphatic MetastasisMaleMiddle AgedNeckNeoplasm Recurrence, LocalNeoplasm, ResidualNeoplasms, Unknown PrimaryRegistriesCervical lymph node metastasesPostoperative radiotherapySquamous cell carcinomaSurgeryUnknown primary tumor

Identifiers

PMID27363402

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.