Evidence map›Paper›PMID 27363389›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2016

BMP1-like proteinases are essential to the structure and wound healing of skin.

Alison M Muir, Dawiyat Massoudi, Ngon Nguyen, Douglas R Keene, Se-Jin Lee, David E Birk, Jeffrey M Davidson, M Peter Marinkovich, Daniel S Greenspan

Open access · greenAbstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 60 citations in OpenAlex.

  1. Variants at 8p21.3 Mediate BMP1 Expression, Contributing to Higher Atopic Dermatitis Risk.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Sensory nerve-secreted factors regulate basal keratinocyte functionIntegrative organismal biology (Oxford, England) · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Effects of bone morphogenetic proteins on epithelial repair.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. The "other" 15-40%: The Role of Non-Collagenous Extracellular Matrix Proteins and Minor Collagens in Tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Alison M MuirDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Dawiyat MassoudiDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Ngon NguyenProgram in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, 94305, USA; Dermatology, VA Medical Center, Palo Alto, CA 94304, USA.
Douglas R KeeneMicroimaging Center, Shriners Hospitals for Children, Portland, OR 97239, USA.
Se-Jin LeeDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
David E BirkDepartment of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
Jeffrey M DavidsonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN 37232, USA; Research Service, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37212, USA.
M Peter MarinkovichProgram in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, 94305, USA; Dermatology, VA Medical Center, Palo Alto, CA 94304, USA.
Daniel S GreenspanDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA. Electronic address: dsgreens@wisc.edu.
University of Wisconsin–Madison · USJohns Hopkins Medicine · USShriners Hospitals for Children - Portland · USStanford University · USUniversity of South Florida · USVA Palo Alto Health Care System · USVA Tennessee Valley Healthcare System · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Transgenic Mouse CoreP01AI084853 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI WILKES, DAVID S · 2010 to 2014
$7.7M
Regulated Assembly of the Tendon Extracellular MatrixR01AR044745 · NIAMS · UNIVERSITY OF SOUTH FLORIDA · PI BIRK, DAVID E · 1997 to 2016
$5.0M
Characterization of Myostatin and GDF-11R01AR060636 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LEE, SE-JIN · 2010 to 2020
$3.7M
Gene Transfer for Recessive Dystrophic Epidermolysis BullosaR01AR055914 · NIAMS · STANFORD UNIVERSITY · PI KHAVARI, PAUL, LANE, ALFRED T · 2009 to 2015
$3.5M
Molecular Biology Of Collagen Type VR01AR047746 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI GREENSPAN, DANIEL S · 2001 to 2013
$3.0M
Mechanisms Underlying Myostatin Regulation and ActivityR01AR059685 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI LEE, SE-JIN · 2010 to 2014
$1.7M
Biology and Pathologies of Type V CollagenR56AR047746 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI GREENSPAN, DANIEL S · 2008 to 2008
$291k
NIAID NIH HHS P01 AI084853NIAMS NIH HHS R01 AR044745NIAMS NIH HHS R01 AR047746NIAMS NIH HHS R01 AR055914NIAMS NIH HHS R01 AR059685NIAMS NIH HHS R01 AR060636NIAMS NIH HHS R56 AR047746NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Closely related extracellular metalloproteinases bone morphogenetic protein 1 (BMP1) and mammalian Tolloid-like 1 (mTLL1) are co-expressed in various tissues and have been suggested to have overlapping roles in the biosynthetic processing of extracellular matrix components. Early lethality of mice null for the BMP1 gene Bmp1 or the mTLL1 gene Tll1 has impaired in vivo studies of these proteinases. To overcome issues of early lethality and functional redundancy we developed the novel BT

Indexed as

AnimalsBiglycanBone Morphogenetic Protein 1Cells, CulturedDecorinDermisGene Knockout TechniquesMaleMice, TransgenicRe-EpithelializationTolloid-Like MetalloproteinasesBgn protein, mouseBiglycanBmp1 protein, mouseBone Morphogenetic Protein 1Dcn protein, mouseDecorinTll1 protein, mouseTolloid-Like MetalloproteinasesBiglycanBone morphogenetic protein 1 (BMP1) mammalian tolloid-like 1CollagenDecorinSkinWound healing

Identifiers

PMID27363389
PMCPMC5136512
OpenAlexW2472825464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.