ArticleOncotarget2016
Superiority of lymph node ratio-based staging system for prognostic prediction in 2575 patients with gastric cancer: validation analysis in a large single center.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Superiority of Tumor Location-Modified Lauren Classification System for Gastric Cancer: A Multi-Institutional Validation Analysis.Annals of surgical oncology · 2018Trial
- Evaluation of three lymph node staging systems for prognostic prediction in gastric cancer: A systematic review and meta-analysis.World journal of gastrointestinal oncology · 2025Article
- Lymph Node Yield and Lymph Node Ratio for Prognosis of Long-Term Survival in Gastric Carcinoma.Cancers · 2025Article
- A prognostic nomogram for predicting overall survival in gastric signet ring cell carcinoma patients: a SEER database and Chinese registry analysis.Frontiers in molecular biosciences · 2025Article
- Separating lymph node stations by the surgeon from the gastric cancer specimen improves the quality of nodal status evaluation.World journal of surgical oncology · 2023Article
- Adjuvant chemotherapy after curative D2 gastrectomy in Latin American patients with gastric cancer.Ecancermedicalscience · 2022Article
- The metastatic lymph node ratio is a better prognostic factor than the number of metastatic limph node after curative resection for gastric cancer.Acta bio-medica : Atenei Parmensis · 2021Article
- Prognostic Factors of Long-term Survival Following Radical Resection for Ampullary Carcinoma.Journal of gastrointestinal cancer · 2021Article
- Identification of an EMT-Related Gene Signature for Predicting Overall Survival in Gastric Cancer.Frontiers in genetics · 2021Article
- Is Preoperative Fibrinogen Associated with the Survival Prognosis of Gastric Cancer Patients? A Multi-centered, Propensity Score-Matched Retrospective Study.World journal of surgery · 2020Article
- Eighth edition of the American Joint Committee on Cancer staging system: are we getting closer to the ideal classification for gastric cancer?Annals of translational medicine · 2019Article
- Modified American Joint Committee on Cancer Tumor-Node-Metastasis Staging System Based on the Node Ratio Can Further Improve the Capacity of Prognosis Assessment for Gastric Cancer Patients.Frontiers in oncology · 2019Article
- Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer.Oncology letters · 2018Article
- Article
- Comparison of different lymph node staging systems in prognosis of gastric cancer: a bi-institutional study from Hungary.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2017Article
- Tumor volume increases the predictive accuracy of prognosis for gastric cancer: A retrospective cohort study of 3409 patients.Oncotarget · 2017Article
- Article
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15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the prognostic significance of node ratio (Nr), the ratio of metastatic to retrieved lymph nodes, and to investigate whether a modified staging system based on Nr can improve prognostic ability for gastric cancer patients following gastrectomy. A total of 2572 patients were randomly divided into training set and validation set, and the cutoff points for Nr were produced using X-tile. The relationships between Nr and other clinicopathologic factors were analyzed, while survival prognostic discriminatory ability and accuracy were compared among different staging systems by AIC and C-index in R program. Patients were categorized into four groups as follows: Nr0, Nr1: 0.00-0.15, Nr2: 0.15-0.40 and Nr3: > 0.40. Nr was significantly associated with clinicopathologic factors including macroscopic type, tumor differentiation, lymphovascular invasion, perineural invasion, tumor size, T stage, N stage and TNM stage. Besides, for all patients, Nr and TNrM staging system showed a smaller AIC and a larger C-index than that of N and TNM staging system, respectively. Moreover, in subgroup analysis for patients with retrieved lymph nodes < 15, Nr was demonstrated to have a smaller AIC and a larger C-index than N staging system. Furthermore, in validation analysis, Nr, categorized by our cutoff points, showed a larger C-index and a smaller AIC value than those produced in previous studies. Nr could be considered as a reliable prognostic factor, even in patients with insufficient (< 15) retrieved lymph nodes, and TNrM staging system may improve the prognostic discriminatory ability and accuracy for gastric cancer patients undergoing radical gastrectomy.
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