Evidence map›Paper›PMID 27363007›Full record

ArticleBrain and cognition2016

The effect of interference on temporal order memory in individuals with Parkinson's disease.

Nicole E DeFord, Kelly M Landy, Eva Pirogovsky-Turk, Emily J Van Etten, Lisa V Graves, David P Salmon, J Vincent Filoteo, Paul E Gilbert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and cognition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicole E DeFordDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Kelly M LandyDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Eva Pirogovsky-TurkDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Emily J Van EttenDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Lisa V GravesSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
David P SalmonDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
J Vincent FiloteoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Paul E GilbertDepartment of Psychology, San Diego State University, San Diego, CA, USA; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA. Electronic address: pgilbert@mail.sdsu.edu.

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHUN, JEROLD · 1985 to 2018
$55.4M
SDSU ADAR ProgramR25AG043364 · NIA · SAN DIEGO STATE UNIVERSITY · PI THEREASA A CRONAN · 2013 to 2026
$5.5M
Mnemonic Processing Deficits in Older Adults at Risk for Alzheimer's DiseaseR01AG034202 · NIA · SAN DIEGO STATE UNIVERSITY · PI GILBERT, PAUL E · 2011 to 2015
$1.1M
Structural_Imaging_of_Visual_Processing_in_AD_and_DLBF31AG039247 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LANDY, KELLY MARIE · 2010 to 2013
$100k
NIA NIH HHS F31 AG039247NIA NIH HHS P50 AG005131NIA NIH HHS R01 AG034202NIA NIH HHS R25 AG043364
6 · The paper itself

Abstract

Memory for the temporal order of items or events in a sequence has been shown to be impaired in older adults and individuals with Parkinson's disease (PD). The present study examined the effects of high and low interference on temporal order memory in individuals diagnosed with PD (n=20) and demographically similar healthy older adults (n=20) utilizing a computerized task used in previously published studies. During the sample phase of each trial, a series of eight circles were randomly presented one at a time in eight different spatial locations. Participants were instructed to remember the sequence in which the circles appeared in the locations. During the choice phase, participants were presented with two circles in two different locations and were asked to indicate which circle appeared earliest in the sample phase sequence. The two circles were separated by one of four possible temporal separation lags (0, 2, 4, and 6), defined as the number of circles occurring in the sample phase sequence between the two choice phase circles. Shorter temporal lags (e.g., 0 and 2 lags) were hypothesized to result in higher interference compared to longer temporal lags (e.g., 4 and 6 lags). The results demonstrated that on trials involving high interference, no differences were found between the two groups. However, healthy older adults significantly outperformed individuals with PD (p<0.05) on trials involving low interference. Although differences were found between the PD and healthy older adult groups, both groups significantly improved on low interference trials compared to high interference trials (p<0.001). The findings indicate that temporal order memory improves in healthy older adults and individuals with PD when interference is reduced. However, individuals with PD demonstrated poorer temporal order memory even with less interference. Therefore, temporal order memory is differentially affected by interference in healthy older adults and individuals with PD. Given that both groups did improve with lessened interference, behavioral interventions that minimize temporal interference potentially could improve memory function in older adults and to a lesser extent in individuals with PD.

Indexed as

AgedFemaleHumansMaleMemoryMiddle AgedParkinson DiseasePsychomotor PerformanceTime FactorsBasal gangliaFrontal lobesInterferenceMemorySequenceVisuospatial

Identifiers

PMID27363007
PMCPMC5802391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.