Evidence map›Paper›PMID 27362882›Full record

ArticleCornea2016

Existence of Normal Limbal Epithelium in Eyes With Clinical Signs of Total Limbal Stem Cell Deficiency.

Eric Chan, Qihua Le, Andres Codriansky, Jiaxu Hong, Jianjian Xu, Sophie X Deng

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cornea, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Regulation of Limbal Epithelial Stem Cells: Importance of the Niche.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eric Chan *David Geffen School of Medicine, University of California, Los Angeles, United States.
Qihua Le *Shanghai Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China.
Andres CodrianskyCornea Division, Stein Eye Institute, University of California, Los Angeles, United States.
Jiaxu HongMassachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, United States.
Jianjian XuShanghai Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China.
Sophie X DengCornea Division, Stein Eye Institute, University of California, Los Angeles, United States.

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY021797
6 · The paper itself

Abstract

purposeTo report the presence of normal limbal epithelium detected by in vivo confocal laser scanning microscopy (IVCM) in 3 cases of clinically diagnosed total limbal stem cell deficiency (LSCD).

methodsThis is a retrospective case report consisting of 3 patients who were diagnosed with total LSCD based on clinical examination and/or impression cytology. Clinical data including ocular history, presentation, slit-lamp examination, IVCM, and impression cytology were reviewed.

resultsThe etiology was chemical burn in 3 cases. One patient had 2 failed penetrating keratoplasties. Another had allogeneic keratolimbal transplantation, but the graft failed 1 year after surgery. The third patient had failed amniotic membrane transplantation. These 3 patients presented with signs of total LSCD including the absence of normal Vogt palisades, complete superficial vascularization of the peripheral cornea, nonhealing epithelial defects, and corneal scarring. Impression cytology was performed in 2 cases to confirm the presence of goblet cells. However, each patient still had distinct areas of corneal and/or limbal epithelial cells detected by IVCM.

conclusionsResidual normal limbal epithelial cells could be present in eyes with clinical features of total LSCD. IVCM seems to be a more accurate method to evaluate the degree of LSCD.

Indexed as

AgedCorneaCorneal DiseasesEpitheliumEpithelium, CornealFemaleHumansLimbus CorneaeMaleMicroscopy, ConfocalMiddle AgedRetrospective StudiesStem Cells

Identifiers

PMID27362882
PMCPMC5067954

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.