Evidence map›Paper›PMID 27362647›Full record

ArticleEpidemiology (Cambridge, Mass.)2017

Survival Analysis with Multiple Causes of Death: Extending the Competing Risks Model.

Margarita Moreno-Betancur, Hamza Sadaoui, Clara Piffaretti, Grégoire Rey

Abstract readVideo-Audio Media
PubMed Publisher
In one paragraph

Article in Epidemiology (Cambridge, Mass.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 72 citations in OpenAlex.

  1. Reclassification and weighting of multiple causes of death: US death certificates 2003-2023.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  5. Underlying and contributing causes of mortality from CDC WONDER-Insights for researchers.American heart journal plus : cardiology research and practice · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Margarita Moreno-BetancurFrom the aClinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, Melbourne, Australia; bDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; cInserm CépiDc, Epidemiology Centre on Medical Causes of Death, Le Kremlin-Bicêtre, France; and dAP-HP, Assistance publique-Hôpitaux de Paris, Paris, France.
Hamza Sadaoui
Clara Piffaretti
Grégoire Rey
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statistics on mortality related to each disease are usually based on the so-called underlying cause of death, which is selected from the diseases declared on the standardized death certificate using international rules. However, the assumption that each death is caused by exactly one disease is debatable, particularly with an aging population in an era where infectious diseases are replaced by chronic and degenerative diseases. The need to consider multiple causes of death has been acknowledged in epidemiologic research, with a growing body of literature producing statistics based on any mention of a disease on the death certificate. Yet there has not been a formal framework proposed for the statistical modeling of death arising from multiple causes. We propose a model for multiple cause of death data grounded on an empirical approach that assigns weights to each cause on the death certificate. We describe how this model for multiple-cause mortality, which extends the usual competing risks model used to conceptualize single-cause mortality, can serve to study the burden and etiology of mortality related to each disease, particularly using Cox regression methodology. We discuss how the multiple-cause, single-cause, and "any-mention" approaches compare in this regard. A simulation study and an application to a study of socioeconomic inequalities in mortality show the value of the proposed methods for exploiting this precious source of data to gain new insights, especially for certain diseases. See video abstract at, http://links.lww.com/EDE/B84.

Indexed as

Cause of DeathModels, StatisticalSurvival AnalysisDeath CertificatesEducational StatusHumansProportional Hazards ModelsRiskSocial Class

Identifiers

PMID27362647
OpenAlexW2473057997

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.