ArticlePloS one2016
Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 62 citations in OpenAlex.
- Copper-driven mutualism ofMicrobiology (Reading, England) · 2026Article
- TheJournal of fungi (Basel, Switzerland) · 2026Article
- Ndt80 Orchestrates Copper Stress Responses and Mitochondrial Homeostasis inJournal of fungi (Basel, Switzerland) · 2026Article
- From Fungicide to Phagosome: A One Health View of Copper-Driven Fungal-Bacterial Interactions.Current clinical microbiology reports · 2026Review
- A roadmap to chemically reactive species: how diverse oxidants affectMicrobiology and molecular biology reviews : MMBR · 2025Review
- Copper-Induced Stimulation of Ectophosphatase Activity ofPathogens (Basel, Switzerland) · 2025Article
- Metals at the Host-Fungal Pathogen Battleground.Annual review of microbiology · 2024Review
- Characterization of a High-Affinity Copper TransporterJournal of fungi (Basel, Switzerland) · 2024Article
- Characterization of a High-Affinity Copper Transporter in the White-Nose Syndrome Causing Fungal PathogenbioRxiv : the preprint server for biology · 2024Article
- Article
- Insights into copper sensing and tolerance inFrontiers in microbiology · 2024Article
- The role of manganese in morphogenesis and pathogenesis of the opportunistic fungal pathogen Candida albicans.PLoS pathogens · 2023Article
- Grf10 regulates the response to copper, iron, and phosphate in Candida albicans.G3 (Bethesda, Md.) · 2023Article
- Pathogenesis and virulence ofVirulence · 2022Review
- Copper Acts Synergistically With Fluconazole inFrontiers in microbiology · 2022Article
- Transcriptional Profiling of the Candida auris Response to Exogenous Farnesol Exposure.mSphere · 2021Article
- Histatin 5 Metallopeptides and Their Potential againstBiomolecules · 2021Review
- The Negative Effect of Protein Phosphatase Z1 Deletion on the Oxidative Stress Tolerance ofJournal of fungi (Basel, Switzerland) · 2021Article
- Ceruloplasmin as a source of Cu for a fungal pathogen.Journal of inorganic biochemistry · 2021Article
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Nutritional immunity is a process whereby an infected host manipulates essential micronutrients to defend against an invading pathogen. We reveal a dynamic aspect of nutritional immunity during infection that involves copper assimilation. Using a combination of laser ablation inductively coupled mass spectrometry (LA-ICP MS) and metal mapping, immunohistochemistry, and gene expression profiling from infected tissues, we show that readjustments in hepatic, splenic and renal copper homeostasis accompany disseminated Candida albicans infections in the mouse model. Localized host-imposed copper poisoning manifests itself as a transient increase in copper early in the kidney infection. Changes in renal copper are detected by the fungus, as revealed by gene expression profiling and fungal virulence studies. The fungus responds by differentially regulating the Crp1 copper efflux pump (higher expression during early infection and down-regulation late in infection) and the Ctr1 copper importer (lower expression during early infection, and subsequent up-regulation late in infection) to maintain copper homeostasis during disease progression. Both Crp1 and Ctr1 are required for full fungal virulence. Importantly, copper homeostasis influences other virulence traits-metabolic flexibility and oxidative stress resistance. Our study highlights the importance of copper homeostasis for host defence and fungal virulence during systemic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.