Evidence map›Paper›PMID 27362506›Full record

Trial reportPediatric research2016

Prenatal DHA supplementation and infant attention.

John Colombo, Kathleen M Gustafson, Byron J Gajewski, D Jill Shaddy, Elizabeth H Kerling, Jocelynn M Thodosoff, Tasha Doty, Caitlin C Brez, Susan E Carlson

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  4. Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018
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  19. External Disruption of Ocular DevelopmentThe Yale journal of biology and medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

John ColomboDepartment of Psychology, Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, Kansas.
Kathleen M GustafsonDepartment of Neurology, University of Kansas Medical Center, Lawrence, Kansas.
Byron J GajewskiDepartment of Biostatistics, University of Kansas Medical Center, Lawrence, Kansas.
D Jill ShaddyDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Lawrence, Kansas.
Elizabeth H KerlingDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Lawrence, Kansas.
Jocelynn M ThodosoffDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Lawrence, Kansas.
Tasha DotyDepartment of Occupational Therapy, Washington University of St. Louis, St. Louis, Missouri.
Caitlin C BrezDepartment of Psychology, Indiana State University, Terre Haute, Indiana.
Susan E CarlsonDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Lawrence, Kansas.
University of Kansas Medical Center · USIndiana State University · USLifeSpan Medical Institute · USWashington University in St. Louis · US

Funding

Research Design and Analysis Core (RDAC)P30HD002528 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 1985 to 2015
$22.1M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
DHA Supplementation and Pregnancy OutcomeR01HD047315 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CARLSON, SUSAN E, COLOMBO, JOHN A. · 2006 to 2016
$4.9M
NICHD NIH HHS P30 HD002528NICHD NIH HHS R01 HD047315NICHD NIH HHS U54 HD090216
6 · The paper itself

Abstract

backgroundResults of randomized trials on the effects of prenatal docosahexaenoic acid (DHA) on infant cognition are mixed, but most trials have used global standardized outcomes, which may not be sensitive to effects of DHA on specific cognitive domains.

methodsWomen were randomized to 600 mg/d DHA or a placebo for the last two trimesters of pregnancy. Infants of these mothers were then followed on tests of visual habituation at 4, 6, and 9 mo of age.

resultsDHA supplementation did not affect look duration or habituation parameters but infants of supplemented mothers maintained high levels of sustained attention (SA) across the first year; SA declined for the placebo group. The supplemented group also showed significantly reduced attrition on habituation tasks, especially at 6 and 9 mo.

conclusionThe findings support with the suggestion that prenatal DHA may positively affect infants' attention and regulation of state.

Indexed as

Dietary SupplementsMaternal Nutritional Physiological PhenomenaAdultAttentionCognitionDocosahexaenoic AcidsFemaleFollow-Up StudiesHeart RateHumansInfantInfant, NewbornMalePregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdDocosahexaenoic Acids

Identifiers

PMID27362506
PMCPMC5164926
OpenAlexW2470265863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.