ArticlePloS one2016
Comorbid Depression and Heart Failure: A Community Cohort Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Cardiovascular diseases and depression: A meta-analysis and Mendelian randomization analysis.Molecular psychiatry · 2025Pooled it
- AIDEBMC geriatrics · 2026Trial
- Depression and Implantable Cardioverter-Defibrillator Implantation in Black Patients at Risk for Sudden Cardiac Death.Journal of the American Heart Association · 2024Trial
- Quality of Life Assessment in Heart Failure Patients: Insights from a Low- to Middle-Income Country.Global heart · 2026Article
- A simple guide to the use of Student's t-test, Mann-Whitney U test, Chi-squared test, and Kruskal-Wallis test in biostatistics.BioData mining · 2025Article
- TaGra: an open Python package for easily generating graphs from data tables through manifold learning.PeerJ. Computer science · 2025Article
- NLRP3 Inflammasome: A New Target for the Treatment of CVD and Depression Comorbidity.Mediators of inflammation · 2025Review
- The DBCV index is more informative than DCSI, CDbw, and VIASCKDE indices for unsupervised clustering internal assessment of concave-shaped and density-based clusters.PeerJ. Computer science · 2025Article
- Strict association between development of psychological conditions and hypertension incidence: A cross-sectional study.Journal of general and family medicine · 2024Article
- Health-Related Quality of Life and Its Association With Outcomes in Adults With Congenital Heart Disease and Heart Failure: Insight From FRESH-ACHD Registry.Journal of the American Heart Association · 2023Article
- Health care providers' perspectives on providing end-of-life psychiatric care in cardiology and oncology hospitals: a cross-sectional questionnaire survey.BMC palliative care · 2023Article
- Associations between cardiac structure and function and depressive disorder: A centenarian study in China.Heliyon · 2023Article
- Taking Care of Us© (TCU) study protocol: feasibility and acceptability of a dyadic intervention for couples living with heart failure.Pilot and feasibility studies · 2023Article
- Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats.AAPS PharmSciTech · 2022Article
- Factors associated with depression among heart failure patients at selected public hospitals in Addis Ababa, Ethiopia: A cross sectional study.PLOS global public health · 2022Article
- Depression Associated with Reduced Heart Rate Variability Predicts Outcome in Adult Congenital Heart Disease.Journal of clinical medicine · 2021Article
- Depression, anxiety and psychological distress in patients with pulmonary hypertension: a mixed-methods study.BMJ open respiratory research · 2021Article
- Symptoms of distress during the COVID-19 pandemic in the United States.American journal of health studies · 2021Article
- Mood Disorders and Increased Risk of Noncommunicable Disease in Adults With HIV.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- The unmeasured burden: Contribution of depression and psychological stress to patient-reported outcomes in atrial fibrillation.International journal of cardiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo examine the association between depression and clinical outcomes in heart failure (HF) in a community cohort. PATIENTS AND
methodsHF patients in Minnesota, United States completed depression screening using the 9-item Patient Health Questionnaire (PHQ-9) between 1st Oct 2007 and 1st Dec 2011; patients with PHQ-9≥5 were labelled "depressed". We calculated the risk of death and first hospitalization within 2 years using Cox regression. Results were adjusted for 10 commonly used prognostic factors (age, sex, systolic blood pressure, estimated glomerular filtration rate, serum sodium, ejection fraction, blood urea nitrogen, brain natriuretic peptide, presence of diabetes and ischaemic aetiology). Area under the curve (AUC), integrated discrimination improvement (IDI) and net reclassification improvement (NRI) compared depression as a predictor against the aforementioned factors.
results425 patients (mean age 74, 57.6% males) were included in the study; 179 (42.1%) had PHQ-9≥5. The adjusted hazard ratio of death was 2.02 (95% CI 1.34-3.04) and of hospitalization was 1.42 (95% CI 1.13-1.80) for those with compared to those without depression. Adding depression to the models did not appreciably change the AUC but led to statistically significant improvements in both the IDI (p = 0.001 and p = 0.005 for death and hospitalization, respectively) and NRI (for death and hospitalization, 35% (p = 0.002) and 27% (p = 0.007) were reclassified correctly, respectively).
conclusionDepression is frequent among community patients with HF and associated with increased risk of hospitalizations and death. Risk prediction for death and hospitalizations in HF patients can be improved by considering depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.