Evidence map›Paper›PMID 27362339›Full record

ArticleNeurocase2016

Delineating potential epileptogenic areas utilizing resting functional magnetic resonance imaging (fMRI) in epilepsy patients.

Ricardo Pizarro, Veena Nair, Timothy Meier, Ryan Holdsworth, Evelyn Tunnell, Paul Rutecki, Karl Sillay, Mary E Meyerand, Vivek Prabhakaran

Abstract read
In one paragraph

Article in Neurocase, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ricardo Pizarroa Department of Biomedical Engineering , UW-Madison , Madison , WI , USA.
Veena Nairb Department of Radiology , UW-Madison , Madison , WI , USA.
Timothy Meierb Department of Radiology , UW-Madison , Madison , WI , USA.
Ryan Holdsworthb Department of Radiology , UW-Madison , Madison , WI , USA.
Evelyn Tunnellc Department of Neurology , UW-Madison , Madison , WI , USA.
Paul Ruteckic Department of Neurology , UW-Madison , Madison , WI , USA.
Karl Sillayd Department of Neurosurgery , UW-Madison , Madison , WI , USA.
Mary E Meyeranda Department of Biomedical Engineering , UW-Madison , Madison , WI , USA.
Vivek Prabhakaranb Department of Radiology , UW-Madison , Madison , WI , USA.

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Research Training for Computation and Informatics in Biology and MedicineT15LM007359 · NLM · UNIVERSITY OF WISCONSIN-MADISON · PI Mark W. Craven, Colin Noel Dewey · 2002 to 2026
$22.6M
NEUROSCIENCE TRAINING PROGRAMT32GM007507 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 1985 to 2017
$9.3M
Training & Education to Advance Minorities in Science (TEAM-Science)R25GM083252 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2008 to 2021
$8.5M
Validating Resting State fMRI Derived Brain ConnectivityRC1MH090912 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI MEYERAND, MARY E. · 2009 to 2010
$999k
NCATS NIH HHS UL1 TR000427NCRR NIH HHS UL1 RR025011NIGMS NIH HHS R25 GM083252NIGMS NIH HHS T32 GM007507NIMH NIH HHS RC1 MH090912NLM NIH HHS T15 LM007359
6 · The paper itself

Abstract

Seizure localization includes neuroimaging like electroencephalogram, and magnetic resonance imaging (MRI) with limited ability to characterize the epileptogenic network. Temporal clustering analysis (TCA) characterizes epileptogenic network congruent with interictal epileptiform discharges by clustering together voxels with transient signals. We generated epileptogenic areas for 12 of 13 epilepsy patients with TCA, congruent with different areas of seizure onset. Resting functional MRI (fMRI) scans are noninvasive, and can be acquired quickly, in patients with different levels of severity and function. Analyzing resting fMRI data using TCA is quick and can complement clinical methods to characterize the epileptogenic network.

Indexed as

HippocampusTemporal LobeAdultElectroencephalographyEpilepsyFunctional NeuroimagingHumansMagnetic Resonance ImagingelectroencephalogramEpilepsyresting function magnetic resonance imagingseizure foci localizationtemporal clustering analysis

Identifiers

PMID27362339
PMCPMC4979575

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.