Evidence map›Paper›PMID 27358914›Full record

ArticleJCI insight2016

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-

David H McMillan, Jos Lj van der Velden, Karolyn G Lahue, Xi Qian, Robert W Schneider, Martina S Iberg, James D Nolin, Sarah Abdalla, Dylan T Casey, Kenneth D Tew and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

  1. Regulated Cell Death in Idiopathic Pulmonary Fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Review
  3. Article
  4. Adaptations in glutathione-based redox protein signaling pathways and alcohol drinking across species.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Antioxidants (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis.American journal of respiratory cell and molecular biology · 2021
    Review
  15. Glutathione S-Transferases in Cancer.Antioxidants (Basel, Switzerland) · 2021
    Review
  16. Frontiers in molecular biosciences · 2021
    Article
  17. Article
  18. Article
  19. Review
  20. Redox RegulationAntioxidants & redox signaling · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 2 countries.

David H McMillanDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Jos Lj van der VeldenDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Karolyn G LahueDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Xi QianDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Robert W SchneiderDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Martina S IbergDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
James D NolinDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Sarah AbdallaDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Dylan T CaseyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Kenneth D TewDepartment of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina, USA.
Danyelle M TownsendDepartment of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina, USA.
Colin J HendersonDivision of Cancer Research, University of Dundee, Dundee, United Kingdom.
C Roland WolfDivision of Cancer Research, University of Dundee, Dundee, United Kingdom.
Kelly J ButnorDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Douglas J TaatjesDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Ralph C BuddDepartment of Medicine and.
Charles G IrvinDepartment of Medicine and.
Albert van der VlietDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Stevenson FlemerDepartment of Chemistry, University of Vermont, Burlington, Vermont, USA.
Vikas AnathyDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
Yvonne Mw Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, University of Vermont, Burlington, Vermont, USA.
University of Vermont · USMedical University of South Carolina · USUniversity of Dundee · GB

Funding

Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Redox-based Fas Signaling in Allergic Airway DiseaseR01HL079331 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI JANSSEN-HEININGER, YVONNE M. W. · 2005 to 2016
$4.2M
Endoplasmic Reticulum Stress Signaling in Allergen-induced Airway RemodelingR01HL122383 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2015 to 2023
$3.5M
Cigarette Smoke-derived Electrophilic Aldehydes and Airway InflammationR01ES021476 · NIEHS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI VAN DER VLIET, ALBERT · 2012 to 2016
$1.9M
GSTP1-mediated Fas S-Glutathionylation, Apoptosis and Lung FibrosisF32HL124902 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MCMILLAN, DAVID HOWARD · 2015 to 2015
$34k
Cancer Research UK 10822Cancer Research UK 15709Cancer Research UK 22357NHLBI NIH HHS F32 HL124902NHLBI NIH HHS R01 HL079331NHLBI NIH HHS R01 HL122383NHLBI NIH HHS T32 HL076122NIEHS NIH HHS R01 ES021476
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease characterized by excessive collagen production and fibrogenesis. Apoptosis in lung epithelial cells is critical in IPF pathogenesis, as heightened loss of these cells promotes fibroblast activation and remodeling. Changes in glutathione redox status have been reported in IPF patients. S-glutathionylation, the conjugation of glutathione to reactive cysteines, is catalyzed in part by glutathione-

Identifiers

PMID27358914
PMCPMC4922427
OpenAlexW2412769416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.