Evidence map›Paper›PMID 27358804›Full record

ArticlePublic health action2016

Timing of antiretroviral therapy and TB treatment outcomes in patients with TB-HIV in Myanmar.

A M Thi, H D Shewade, N T T Kyaw, M M Oo, T K Aung, S T Aung, H N Oo, T Win, A D Harries

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In one paragraph

Article in Public health action, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

A M ThiInternational Union Against Tuberculosis and Lung Disease (The Union), Mandalay, Myanmar.
H D ShewadeThe Union, South-East Asia Office, New Delhi, India.
N T T KyawInternational Union Against Tuberculosis and Lung Disease (The Union), Mandalay, Myanmar.
M M OoInternational Union Against Tuberculosis and Lung Disease (The Union), Mandalay, Myanmar.
T K AungInternational Union Against Tuberculosis and Lung Disease (The Union), Mandalay, Myanmar.
S T AungNational Tuberculosis Programme, Ministry of Health, Nay Pyi Taw, Myanmar.
H N OoNational AIDS Programme (NAP), Ministry of Health, Nay Pyi Taw, Myanmar.
T WinNAP, Ministry of Health, Mandalay, Myanmar.
A D HarriesThe Union, Paris, France ; London School of Hygiene & Tropical Medicine, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

settingIntegrated HIV Care programme, Mandalay, Myanmar.

objectivesTo determine time to starting antiretroviral treatment (ART) in relation to anti-tuberculosis treatment (ATT) and its association with TB treatment outcomes in patients co-infected with tuberculosis (TB) and the human immunodeficiency virus (HIV) enrolled from 2011 to 2014.

designRetrospective cohort study.

resultsOf 1708 TB-HIV patients, 1565 (92%) started ATT first and 143 (8%) started ART first. Treatment outcomes were missing for 226 patients and were thus not included. In those starting ATT first, the median time to starting ART was 8.6 weeks. ART was initiated after 8 weeks in 830 (53%) patients. Unsuccessful outcome was found in 7%, with anaemia being an independent predictor. In patients starting ART first, the median time to starting ATT was 21.6 weeks. ATT was initiated within 3 months in 56 (39%) patients. Unsuccessful outcome was found in 12%, and in 20% of those starting ATT within 3 months. Patients with CD4 count <100/mm(3) had a four times higher risk of an unsuccessful outcome.

conclusionsTiming of ART in relation to ATT was not an independent risk factor for unsuccessful outcome. Extensive screening for TB with rapid and sensitive diagnostic tests in HIV-infected persons and close monitoring of anaemia and immunosuppression are recommended to further improve TB treatment outcomes among patients with TB-HIV.

Indexed as

adverse TB treatment outcomesearly ART initiationHIV-associated TBoperational researchSORT ITtreatment outcome

Identifiers

PMID27358804
PMCPMC4913673

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