ArticleAnnals of medicine and surgery (2012)2016
Arginine dimethylation products in pediatric patients with chronic kidney disease.
Article in Annals of medicine and surgery (2012), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Independent Associations Between Arginine-Related Metabolites and Disease Activity in Pediatric Asthma: A Multivariable Biomarker Study.Biomolecules · 2026Article
- Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride.Journal of pharmaceutical analysis · 2024Article
- Nitric Oxide Synthesis Metabolites-As Potential Markers in Chronic Kidney Disease in Children.Current issues in molecular biology · 2022Article
- Dimethylarginines in Children after Anti-Neoplastic Treatment.Medicina (Kaunas, Lithuania) · 2022Article
- Article
- Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney.Frontiers in physiology · 2020Review
- Symmetric dimethylarginine concentrations in dogs with International Renal Interest Society stage 4 chronic kidney disease undergoing intermittent hemodialysis.Journal of veterinary internal medicine · 2019Article
- Pathophysiology and treatment of cardiovascular disease in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Contribution of symmetric dimethylarginine to GFR decline in pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2018Observational
- Quantitative Analysis of l-Arginine, Dimethylated Arginine Derivatives, l-Citrulline, and Dimethylamine in Human Serum Using Liquid Chromatography-Mass Spectrometric Method.Chromatographia · 2018Article
- Asymmetric Dimethylarginine and Its Relation As a Biomarker in Nephrologic Diseases.Biomarker insights · 2016Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundarginine and its metabolites have been linked to pediatric chronic kidney disease (CKD). We aimed to estimate serum levels of argninine (Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in pediatric CKD patients and its relation to altered kidney function. PATIENTS AND
methods132 pediatric patients with CKD and 120 healthy age and sex matched controls were compared regarding; serum Arg, ADMA and SDMA levels.
resultsIn comparison to their values in control subjects, serum Arg levels were significantly lower; serum ADMA levels were non-significantly higher, but serum SDMA levels were significantly higher in CKD patients (p values: < 0.000; = 0.054; <0.000, respectively). Calculated Arg/ADMA and Arg/SDMA ratios were significantly higher in patients compared to controls (p values: 0.001, and <0.000, respectively). However ADMA/SDMA ratio was significantly lower in patients compared to controls (p = 0.001. Serum Arg levels showed positive significant correlation, while serum ADMA and SDMA levels showed negative significant correlation with eGFR. Moreover, Arg/ADMA ratio showed negative significant correlation, while ADMA/SDMA ratio showed positive significant correlation with eGFR of patients. Regression analysis defined high serum SDMA level as persistently significant predictor for low eGFR.
conclusionDisturbed serum levels of arginine and its dimethyl derivatives may underlie development and/or progression of CKD. Elevated serum SDMA level is strongly correlated with impaired kidney functions and could be considered as a predictor for kidney functions deterioration and CKD progression.
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