Evidence map›Paper›PMID 27358720›Full record

ArticleMolecular autism2016

Data from the Baby Siblings Research Consortium confirm and specify the nature of the female protective effect in autism: A commentary on Messinger et al.

John N Constantino

Abstract readComment
In one paragraph

Article in Molecular autism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. The social brain in female autism: a structural imaging study of twins.Social cognitive and affective neuroscience · 2020
    Article
  3. Review
  4. Opposite Expression Patterns ofFrontiers in psychiatry · 2019
    Article
  5. Article
  6. Deconstructing autism: from unitary syndrome to contributory developmental endophenotypes.International review of psychiatry (Abingdon, England) · 2018
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

John N ConstantinoBlanche F. Ittleson Professor of Psychiatry and Pediatrics, William Greenleaf Eliot Division of Child Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, Campus Box 8504, St. Louis, MO 63110 USA.

Funding

Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI MOLEY, KELLE H · 2015 to 2019
$7.1M
NICHD NIH HHS U54 HD087011
6 · The paper itself

Abstract

Sibling recurrence data from the Baby Siblings Research Consortium (BSRC) recapitulate results from very large clinical family studies that demonstrate the absence of the Carter effect and provide clarification of the nature of the female protective effect in ASD. This legacy prospective data collection confirmed marked differences in the proportions of males versus females who lie along deviant trajectories of social development in the setting of inherited liability to autism--a phenomenon which defines the female protective effect--and demonstrate that among affected children, sex differences are modest and homologous to those observed among non-ASD children.

Indexed as

Autism spectrum disorderCompensatoryFemale protective effectResilienceSex

Identifiers

PMID27358720
PMCPMC4926292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.