Evidence map›Paper›PMID 27358719›Full record

ArticleMolecular autism2016

Commentary: sex difference differences? A reply to Constantino.

Daniel S Messinger, Gregory S Young, Sara Jane Webb, Sally Ozonoff, Susan E Bryson, Alice Carter, Leslie Carver, Tony Charman, Katarzyna Chawarska, Suzanne Curtin and 9 more

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Daniel S MessingerUniversity of Miami, Coral Gables, USA.
Gregory S YoungUniversity of California, Davis, Davis, USA.
Sara Jane WebbSeattle Children's Research Institute, Seattle, USA ; University of Washington, Seattle, USA.ORCID 0000-0003-4101-6255
Sally OzonoffUniversity of California, Davis, Davis, USA.
Susan E BrysonIzaak Walton Killam Health Centre, Halifax, Canada ; Dalhousie University, Halifax, Canada.
Alice CarterUniversity of Massachusetts, Boston, Boston, USA.
Leslie CarverUniversity of California, San Diego, La Jolla, USA.
Tony CharmanKing's College London, London, UK.
Katarzyna ChawarskaYale University School of Medicine, New Haven, USA.
Suzanne CurtinUniversity of Calgary, Calgary, Canada.
Karen DobkinsUniversity of California, San Diego, La Jolla, USA.
Irva Hertz-PicciottoUniversity of California, Davis, Davis, USA.
Ted HutmanUniversity of California, Los Angeles, Los Angeles, USA.
Jana M IversonUniversity of Pittsburgh, Pittsburgh, USA.
Rebecca LandaKennedy Krieger Institute, Baltimore, USA ; John Hopkins School of Medicine, Baltimore, USA.
Charles A NelsonHarvard Medical School, Boston, USA ; Harvard Graduate School of Education, Cambridge, USA ; Boston Children's Hospital, Boston, USA.
Wendy L StoneUniversity of Washington, Seattle, USA.
Helen Tager-FlusbergBoston University, Boston, USA.
Lonnie ZwaigenbaumUniversity of Alberta, Edmonton, Canada.

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2007 to 2021
$32.0M
TOURETTE'S SYNDROME &RELATED DISORDERS: STUDY OF HIGH DENSITY FAMILIESP01HD003008 · NICHD · YALE UNIVERSITY · PI VOLKMAR, FRED ROBERT · 1985 to 2010
$12.1M
UW Autism Center of ExcellenceP50HD055782 · NICHD · UNIVERSITY OF WASHINGTON · PI KING, BRYAN H · 2007 to 2011
$11.0M
Autism: Social And Communication Predictors in SiblingsR01MH059630 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LANDA, REBECCA JEAN · 2001 to 2016
$10.7M
Social &Language Deficits in Autism-Biology &TreamentU54MH068172 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIGMAN, MARIAN D · 2003 to 2007
$8.2M
Intellectual and Developmental Disabilities Research CenterU54HD083091 · NICHD · UNIVERSITY OF WASHINGTON · PI DOHERTY, DANIEL · 2014 to 2019
$7.9M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI WILSON, MARY A · 2014 to 2019
$7.9M
Neurobehavioral Research on Infants at Risk for SLI and AutismR01DC010290 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, CHARLES ALEXANDER, TAGER-FLUSBERG, HELEN · 2009 to 2020
$7.5M
Infants at Risk of Autism: A Longitudinal StudyR01MH068398 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI OZONOFF, SALLY · 2003 to 2013
$6.1M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2M
Social-Emotional Development of Infants At Risk for Autism SpectrumR01HD057284 · NICHD · VANDERBILT UNIVERSITY · PI MESSINGER, DANIEL S, STONE, WENDY L. · 2008 to 2012
$3.1M
Early Identification of Autism: A Prospective StudyR01HD054979 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI IVERSON, JANA M · 2007 to 2011
$2.7M
Canadian Institutes of Health ResearchMedical Research CouncilNICHD NIH HHS P01 HD003008NICHD NIH HHS P01HD003008NICHD NIH HHS P50 HD055782NICHD NIH HHS P50HD055782NICHD NIH HHS P50 HD055784NICHD NIH HHS P50 HD55784NICHD NIH HHS R01 HD054979NICHD NIH HHS R01HD054979NICHD NIH HHS R01 HD057284NICHD NIH HHS R01HD057284NICHD NIH HHS R01 HD064820NICHD NIH HHS R01HD064820NICHD NIH HHS U54 HD079123NICHD NIH HHS U54 HD083091NICHD NIH HHS U54 HD090255NIDCD NIH HHS R01 DC010290NIDCD NIH HHS R01DC010290NIDCD NIH HHS R21 DC008637NIDCD NIH HHS R21DC008637NIGMS NIH HHS R01 GM105004NIGMS NIH HHS R01GM105004NIMH NIH HHS K01 MH096961NIMH NIH HHS K01MH096961NIMH NIH HHS R01 MH059630NIMH NIH HHS R01MH059630NIMH NIH HHS R01 MH068398NIMH NIH HHS R01MH068398NIMH NIH HHS R01 MH087554NIMH NIH HHS R01MH087554NIMH NIH HHS U54 MH068172
6 · The paper itself

Abstract

Messinger et al. found a 3.18 odds ratio of male to female ASD recurrence in 1241 prospectively followed high-risk (HR) siblings. Among high-risk siblings (with and without ASD), as well as among 583 low-risk controls, girls exhibited higher performance on the Mullen Scales of Early Learning, as well as lower restricted and repetitive behavior severity scores on the Autism Diagnostic Observation Schedule (ADOS) than boys. That is, female-favoring sex differences in developmental performance and autism traits were evident among low-risk and non-ASD high-risk children, as well as those with ASD. Constantino (Mol Autism) suggests that sex differences in categorical ASD outcomes in Messinger et al. should be understood as a female protective effect. We are receptive to Constantino's (Mol Autism) suggestion, and propose that quantitative sex differences in autism-related features are keys to understanding this female protective effect.

Indexed as

Autism spectrum disorderFemale protective effectHigh-risk siblingsSex differences

Identifiers

PMID27358719
PMCPMC4926305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.