Observational studyPediatrics2016
Characteristics of Children and Adolescents With Multiple Sclerosis.
Observational study in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.
- ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: Improving immunization strategies in the era of highly active immunotherapeutic drugs.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Pooled it
- Exploring Healthcare Continuity in Pediatric-Onset Multiple Sclerosis in the United States.Annals of the Child Neurology Society · 2026Article
- Can Multiple Sclerosis be Managed Over a Lifetime? A Rare 72-Year Journey of Pediatric-Onset to Secondary Progressive Multiple Sclerosis.Clinical case reports · 2026Article
- Adaptation of the Transition Readiness Assessment Questionnaire for Pediatric-Onset Multiple Sclerosis: Protocol for a User-Centered Design Approach.JMIR research protocols · 2026Article
- Health care use preceding pediatric multiple sclerosis: A population-based study from Ontario, Canada.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Predictors of a relapsing course in myelin oligodendrocyte glycoprotein antibody-associated disease.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex.Journal of neurology · 2024Article
- Parental Experiences in Pediatric Multiple Sclerosis: Insights from Quantitative Research.Children (Basel, Switzerland) · 2024Review
- Myelin oligodendrocyte glycoprotein antibody-associated disease as a novel presentation of central nervous system autoimmunity in a pediatric patient with Wiskott-Aldrich syndrome.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Gene-environment interactions increase the risk of paediatric-onset multiple sclerosis associated with household chemical exposures.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Altered Lnc-EGFR, SNHG1, and LincRNA-Cox2 Profiles in Patients with Relapsing-Remitting Multiple Sclerosis: Impact on Disease Activity and Progression.Diagnostics (Basel, Switzerland) · 2023Article
- A Gender-Based Point of View in Pediatric Neurology.Journal of personalized medicine · 2023Review
- Socioeconomic, Clinical, and Laboratory Parameters Differentiating Pediatric Patients With MOG Antibody-Associated Disease and Multiple Sclerosis.Journal of child neurology · 2023Article
- Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population.Children (Basel, Switzerland) · 2023Article
- Recent progress in epidemiology, clinical features, and therapy of multiple sclerosis in China.Therapeutic advances in neurological disorders · 2023Review
- Narrative review based on fingolimod therapy in pediatric MS.SAGE open medicine · 2023Review
- Clinical and Epidemiological Findings of Pediatric Onset Multiple Sclerosis in East-Azerbaijan, Iran; A Population-based Study.Iranian journal of child neurology · 2023Article
- Clinical and MRI characteristics of multiple sclerosis in Iranian Children and Adolescents.Iranian journal of child neurology · 2023Article
- The Clinical and Epidemiological Profile of Paediatric-Onset Multiple Sclerosis in Poland.Journal of clinical medicine · 2022Article
- Endocardium in Hypoplastic Left Heart Syndrome: Implications from In Vitro Study.Journal of cardiovascular development and disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 11 institutions in 1 country.
Funding
Abstract
objectivesTo describe the demographic and clinical characteristics of pediatric multiple sclerosis (MS) in the United States.
methodsThis prospective observational study included children and adolescents with MS. Cases were evaluated across 9 geographically diverse sites as part of the US Network of Pediatric MS Centers.
resultsA total of 490 children and adolescents (324 girls, 166 boys) were enrolled; 28% developed symptoms before 12 years of age. The proportion of girls increased with age from 58% (<12 years) to 70% (≥12 years). Race and ethnicity as self-identified were: white, 67%; African American, 21%; and non-Hispanic, 70%. Most (94%) of the cases were born in the United States, and 39% had 1 or both foreign-born parents. Fifty-five percent of cases had a monofocal presentation; 31% had a prodrome (most frequently infectious), most often among those aged <12 years (P < .001). Children aged <12 years presented more commonly with encephalopathy and coordination problems (P < .001). Sensory symptoms were more frequently reported by older children (ie, those aged ≥12 years) (P < .001); 78% of girls had MS onset postmenarche. The initial Expanded Disability Status Scale score for the group was <3.0, and the annualized relapse rate was 0.647 for the first 2 years. Interval from symptom onset to diagnosis and from diagnosis to initiation of disease-modifying therapy was longer among those <12 years of age.
conclusionsPediatric MS in the United States is characterized by racial and ethnic diversity, a high proportion of children with foreign-born parents, and differences in clinical features and timing of treatment among those <12 years of age compared with older children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.