ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Lasting Adaptations in Social Behavior Produced by Social Disruption and Inhibition of Adult Neurogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 60 citations in OpenAlex.
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- Building a social brain: Cells, circuits and behavior across the lifespan.Neurobiology of stress · 2025Review
- Effects of Testosterone and Its Major Metabolites upon Different Stages of Neuron Survival in the Dentate Gyrus of Male Rats.Biomolecules · 2025Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Therapeutic uses of oxytocin in stress-related neuropsychiatric disorders.Cell & bioscience · 2023Review
- Hypobaric Hypoxia Induces Deficits in Adult Neurogenesis and Social Interaction via Cyclooxygenase-1/ EP1 Receptor Pathway Activating NLRP3 Inflammasome.Molecular neurobiology · 2022Article
- Shaping social behavior in an enriched environment.Frontiers in behavioral neuroscience · 2022Article
- Bidirectional control of infant rat social behavior via dopaminergic innervation of the basolateral amygdala.Neuron · 2021Article
- Novel competition test for food rewards reveals stable dominance status in adult male rats.Scientific reports · 2021Article
- Adult-born granule cell mossy fibers preferentially target parvalbumin-positive interneurons surrounded by perineuronal nets.Hippocampus · 2021Article
- Adult neurogenesis alters response to an aversive distractor in a labyrinth maze without affecting spatial learning or memory.Hippocampus · 2021Article
- Reproduction-Associated Hormones and Adult Hippocampal Neurogenesis.Neural plasticity · 2021Review
- Defining Immediate Effects of Sensitive Periods on Infant Neurobehavioral Function.Current opinion in behavioral sciences · 2020Article
- Stress in groups: Lessons from non-traditional rodent species and housing models.Neuroscience and biobehavioral reviews · 2020Review
- Functional neurogenesis over the years.Behavioural brain research · 2020Review
- Stress Varies Along the Social Density Continuum.Frontiers in systems neuroscience · 2020Review
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
unlabelledResearch on social instability has focused on its detrimental consequences, but most people are resilient and respond by invoking various coping strategies. To investigate cellular processes underlying such strategies, a dominance hierarchy of rats was formed and then destabilized. Regardless of social position, rats from disrupted hierarchies had fewer new neurons in the hippocampus compared with rats from control cages and those from stable hierarchies. Social disruption produced a preference for familiar over novel conspecifics, a change that did not involve global memory impairments or increased anxiety. Using the neuropeptide oxytocin as a tool to increase neurogenesis in the hippocampus of disrupted rats restored preference for novel conspecifics to predisruption levels. Conversely, reducing the number of new neurons by limited inhibition of adult neurogenesis in naive transgenic GFAP-thymidine kinase rats resulted in social behavior similar to disrupted rats. Together, these results provide novel mechanistic evidence that social disruption shapes behavior in a potentially adaptive way, possibly by reducing adult neurogenesis in the hippocampus. SIGNIFICANCE STATEMENT: To investigate cellular processes underlying adaptation to social instability, a dominance hierarchy of rats was formed and then destabilized. Regardless of social position, rats from disrupted hierarchies had fewer new neurons in the hippocampus compared with rats from control cages and those from stable hierarchies. Unexpectedly, these changes were accompanied by changes in social strategies without evidence of impairments in cognition or anxiety regulation. Restoring adult neurogenesis in disrupted rats using oxytocin and conditionally suppressing the production of new neurons in socially naive GFAP-thymidine kinase rats showed that loss of 6-week-old neurons may be responsible for adaptive changes in social behavior.
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