ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016
ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- Postprandial dynamics of sensory receptor and neural mechanisms underlying feeding regulation in mule ducks.Poultry science · 2026Article
- Sociodemographic and biochemical correlates of self-reported taste dysfunction: an NHANES analysis.Open medicine (Warsaw, Poland) · 2026Article
- Fyn Kinase: A Potential Target in Glucolipid Metabolism and Diabetes Mellitus.Current issues in molecular biology · 2025Review
- A mechanism of CALHM1 ion channel gating.American journal of physiology. Cell physiology · 2025Article
- T1R2/T1R3 polymorphism affects sweet and fat perception: Correlation between SNP and BMI in the context of obesity development.Human genetics · 2025Article
- Effects of a Plant-Based Diet During the First Month of Feeding on Alevin Rainbow Trout (Aquaculture nutrition · 2025Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.Physiology & behavior · 2022Article
- Cellular and Molecular Mechanisms of Fat Taste Perception.Handbook of experimental pharmacology · 2022Article
- Article
- Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases.Biomolecules · 2020Review
- Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice.Journal of lipid research · 2020Article
- An improved method for examining fat taste.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Single-nucleotide polymorphism rs1761667 in theJournal of nutritional science · 2020Article
- Mammalian Taste Cells Express Functional Olfactory Receptors.Chemical senses · 2019Article
- Greater reductions in fat preferences in CALHM1 than CD36 knockout mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Genome-Wide Association Studies Associated with Backfat Thickness in Landrace and Yorkshire Pigs.Genomics & informatics · 2018Article
- Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells.PloS one · 2018Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
Abstract
Obesity is a major public health problem. An in-depth knowledge of the molecular mechanisms of oro-sensory detection of dietary lipids may help fight it. Humans and rodents can detect fatty acids via lipido-receptors, such as CD36 and GPR120. We studied the implication of the MAPK pathways, in particular, ERK1/2, in the gustatory detection of fatty acids. Linoleic acid, a dietary fatty acid, induced via CD36 the phosphorylation of MEK1/2-ERK1/2-ETS-like transcription factor-1 cascade, which requires Fyn-Src kinase and lipid rafts in human taste bud cells (TBCs). ERK1/2 cascade was activated by Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.