ArticleProceedings. Biological sciences2016
A possible role of DNA methylation in functional divergence of a fast evolving duplicate gene encoding odorant binding protein 11 in the honeybee.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics.Advances in experimental medicine and biology · 2022Article
- Expansion and Accelerated Evolution of 9-Exon Odorant Receptors in Polistes Paper Wasps.Molecular biology and evolution · 2021Article
- The impact of epigenetic information on genome evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Novel structure in the nuclei of honey bee brain neurons revealed by immunostaining.Scientific reports · 2021Article
- Article
- Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020Review
- Venomics of the ectoparasitoid wasp Bracon nigricans.BMC genomics · 2020Article
- Changes of gene expression but not cytosine methylation are associated with male parental care reflecting behavioural state, social context and individual flexibility.The Journal of experimental biology · 2019Article
- Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee.Frontiers in physiology · 2019Article
- Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development.Genome research · 2018Article
- Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites.Epigenetics · 2018Article
- Various Bee Pheromones Binding Affinity, Exclusive Chemosensillar Localization, and Key Amino Acid Sites Reveal the Distinctive Characteristics of Odorant-Binding Protein 11 in the Eastern Honey Bee,Frontiers in physiology · 2018Article
- Detecting rare asymmetrically methylated cytosines and decoding methylation patterns in the honeybee genome.Royal Society open science · 2017Article
- Article
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3 authors.
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Abstract
Although gene duplication is seen as the main path to evolution of new functions, molecular mechanisms by which selection favours the gain versus loss of newly duplicated genes and minimizes the fixation of pseudo-genes are not well understood. Here, we investigate in detail a duplicate honeybee gene obp11 belonging to a fast evolving insect gene family encoding odorant binding proteins (OBPs). We report that obp11 is expressed only in female bees in rare antennal sensilla basiconica in contrast to its tandem partner obp10 that is expressed in the brain in both females and males (drones). Unlike all other obp genes in the honeybee, obp11 is methylated suggesting that functional diversification of obp11 and obp10 may have been driven by an epigenetic mechanism. We also show that increased methylation in drones near one donor splice site that correlates with higher abundance of a transcript variant encoding a truncated OBP11 protein is one way of controlling its contrasting expression. Our data suggest that like in mammals and plants, DNA methylation in insects may contribute to functional diversification of proteins produced from duplicated genes, in particular to their subfunctionalization by generating complementary patterns of expression.
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