Evidence map›Paper›PMID 27358354›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016

Durable Viral Suppression and Transmission Risk Potential Among Persons With Diagnosed HIV Infection: United States, 2012-2013.

Nicole Crepaz, Tian Tang, Gary Marks, Michael J Mugavero, Lorena Espinoza, H Irene Hall

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nicole CrepazDivision of HIV/AIDS Prevention, US Centers for Disease Control and Prevention.
Tian TangICF International, Atlanta, Georgia.
Gary MarksDivision of HIV/AIDS Prevention, US Centers for Disease Control and Prevention.
Michael J MugaveroDepartment of Medicine, Division of Infectious Diseases, University of Alabama, Birmingham.
Lorena EspinozaDivision of HIV/AIDS Prevention, US Centers for Disease Control and Prevention.
H Irene HallDivision of HIV/AIDS Prevention, US Centers for Disease Control and Prevention.
Centers for Disease Control and Prevention · UGICF International (United States) · USUniversity of Alabama at Birmingham · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundWe examined durable viral suppression, cumulative viral load (VL) burden, and transmission risk potential among human immunodeficiency virus (HIV)-diagnosed persons in care.

methodsUsing data from the National HIV Surveillance System from 17 jurisdictions with complete reporting of VL test results, we determined the percentage of persons in HIV care who achieved durable viral suppression (all VL results <200 copies/mL) and examined viremia copy-years and time spent above VL levels that increase the risk of HIV transmission during 2012-2013.

resultsOf 265 264 persons in HIV care in 2011, 238 641 had at least 2 VLs in 2012-2013. The median number of VLs per individual during the 2-year period was 5. Approximately 62% had durable viral suppression. The remaining 38% had high VL burden (geometric mean of viremia copy-years, 7261) and spent an average of 438 days, 316 days, and 215 days (60%, 43.2%, and 29.5% of the 2-year period) above 200, 1500, and 10 000 copies/mL. Women, blacks/African Americans, Hispanics/Latinos, persons with HIV infection attributed to transmission other than male-to-male sexual contact, younger age groups, and persons with gaps in care had higher viral burden and transmission risk potential.

conclusionsTwo-thirds of persons in HIV care had durable viral suppression during a 2-year period. One-third had high VL burden and spent substantial time above VL levels with increased risk of onward transmission. More intervention efforts are needed to improve retention in care and medication adherence so that more persons in HIV care achieve durable viral suppression.

Indexed as

HIV InfectionsAdolescentAdultAnti-HIV AgentsFemaleHIV-1HumansMaleMiddle AgedRiskSustained Virologic ResponseUnited StatesViral LoadYoung AdultAnti-HIV Agentsdisparitydurable viral suppressionHIV-diagnosed personsHIV transmission riskviral burden

Identifiers

PMID27358354
PMCPMC5021630
OpenAlexW2467253582

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.