ArticleJournal of the Royal Society, Interface2016
High turnover drives prolonged persistence of influenza in managed pig herds.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanistic Models of Influenza Transmission in Commercial Swine Populations: A Systematic Review.Pathogens (Basel, Switzerland) · 2024Pooled it
- Epidemiology of Influenza A virus in Swiss pig herds: subclinical circulation and associated risk factors.Porcine health management · 2026Article
- Influenza A virus infection dynamics in two sow herds and effects of interventions.Porcine health management · 2026Article
- Epidemiology and Risk Modelling of Influenza A Virus Within and Between Pig Herds in Northern Lao PDR.Transboundary and emerging diseases · 2026Article
- Active surveillance for influenza A virus in swine reveals within-farm reassortment and cocirculation of distinct subtypes and genetic clades.Veterinary microbiology · 2025Article
- Integrating behavioural science and epidemiology to improve early detection of zoonotic swine influenza in the Netherlands.One health (Amsterdam, Netherlands) · 2025Article
- Evolutionary dynamics and molecular epidemiology of H1N1 pandemic 2009 influenza A viruses across swine farms in Denmark.Virus evolution · 2025Article
- Dynamic of swine influenza virus infection in weaned piglets in five enzootically infected herds in Germany, a cohort study.Porcine health management · 2024Article
- Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets.NPJ vaccines · 2024Article
- Article
- Swine influenza A virus infection dynamics and evolution in intensive pig production systems.Virus evolution · 2024Article
- Emergence of swine influenza A virus, porcine respirovirus 1 and swine orthopneumovirus in porcine respiratory disease in Germany.Emerging microbes & infections · 2023Article
- Seroprevalence of Swine Influenza A Virus (swIAV) Infections in Commercial Farrow-to-Finish Pig Farms in Greece.Veterinary sciences · 2023Article
- A stochastic compartmental model to simulate intra- and inter-species influenza transmission in an indoor swine farm.PloS one · 2023Article
- Understanding the relative risks of zoonosis emergence under contrasting approaches to meeting livestock product demand.Royal Society open science · 2022Article
- Infectious disease in an era of global change.Nature reviews. Microbiology · 2022Review
- Zoonotic and reverse zoonotic transmission of viruses between humans and pigs.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021Review
- Review
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- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Pigs have long been hypothesized to play a central role in the emergence of novel human influenza A virus (IAV) strains, by serving as mixing vessels for mammalian and avian variants. However, the key issue of viral persistence in swine populations at different scales is ill understood. We address this gap using epidemiological models calibrated against seroprevalence data from Dutch finishing pigs to estimate the 'critical herd size' (CHS) for IAV persistence. We then examine the viral phylogenetic evidence for persistence by comparing human and swine IAV. Models suggest a CHS of approximately 3000 pigs above which influenza was likely to persist, i.e. orders of magnitude lower than persistence thresholds for IAV and other acute viruses in humans. At national and regional scales, we found much stronger empirical signatures of prolonged persistence of IAV in swine compared with human populations. These striking levels of persistence in small populations are driven by the high recruitment rate of susceptible piglets, and have significant implications for management of swine and for overall patterns of genetic diversity of IAV.
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Registered trials
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