ArticleScientific reports2016
A Structure-free Method for Quantifying Conformational Flexibility in proteins.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Structural and Mechanical Dynamics of Polymer Membranes Across Multilength Scales.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Evolution of the RNA alternative decayRNA biology · 2025Article
- SAXS Assistant: Automated SAXS analysis for structural discovery in biologics and polymeric nanoparticles.Biophysical journal · 2025Article
- Repurposed pharmacotherapy: targeting cathepsin L with repurposed drugs in virtual screening.Molecular diversity · 2025Article
- Monte Carlo Simulations of Polymer Collapse in an Explicit Solvent of Varying Quality.Polymers · 2025Article
- Identification of an Intrinsically Disordered Region (IDR) in Arginyltransferase 1 (ATE1).Biochemistry · 2024Article
- The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures.Structure (London, England : 1993) · 2024Article
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- Characterization and structural analysis of alcohol-fractionated lignin biofuels processed at ambient temperature.Heliyon · 2024Article
- Identification of an intrinsically disordered region (IDR) in arginyltransferase 1 (ATE1).bioRxiv : the preprint server for biology · 2024Article
- Porous Semiconducting Polymer Nanoparticles as Intracellular Biophotonic Mediators to Modulate the Reactive Oxygen Species Balance.Nano letters · 2024Article
- Heme-substituted protein assembly bridged by synthetic porphyrin: achieving controlled configuration while maintaining rotational freedom.RSC advances · 2024Article
- Visualization of conformational transition of GRP94 in solution.Life science alliance · 2024Article
- Getting Smaller by Denaturation: Acid-Induced Compaction of Antibodies.The journal of physical chemistry letters · 2023Article
- Interrogating Encapsulated Protein Structure within Metal-Organic Frameworks at Elevated Temperature.Journal of the American Chemical Society · 2023Article
- When does a macromolecule transition from a polymer chain to a nanoparticle?Nanoscale advances · 2022Article
- Solution characterization of the dynamic conjugative entry exclusion protein TraG.Structural dynamics (Melville, N.Y.) · 2022Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
All proteins sample a range of conformations at physiologic temperatures and this inherent flexibility enables them to carry out their prescribed functions. A comprehensive understanding of protein function therefore entails a characterization of protein flexibility. Here we describe a novel approach for quantifying a protein's flexibility in solution using small-angle X-ray scattering (SAXS) data. The method calculates an effective entropy that quantifies the diversity of radii of gyration that a protein can adopt in solution and does not require the explicit generation of structural ensembles to garner insights into protein flexibility. Application of this structure-free approach to over 200 experimental datasets demonstrates that the methodology can quantify a protein's disorder as well as the effects of ligand binding on protein flexibility. Such quantitative descriptions of protein flexibility form the basis of a rigorous taxonomy for the description and classification of protein structure.
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