Evidence map›Paper›PMID 27357749›Full record

ArticleScientific reports2016

An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling.

Fernando Aleman, Junshi Yazaki, Melissa Lee, Yohei Takahashi, Alice Y Kim, Zixing Li, Toshinori Kinoshita, Joseph R Ecker, Julian I Schroeder

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
37.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 262 citations in OpenAlex.

  1. Article
  2. Article
  3. Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026
    Review
  4. Article
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  6. Review
  7. Review
  8. Article
  9. Transcriptome Analysis and Functional Validation of JAZ Subfamily Genes ofInternational journal of molecular sciences · 2026
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Fernando AlemanDivision of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, California, USA.
Junshi YazakiPlant Biology Laboratory, Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, California, 92037 USA.
Melissa LeeDivision of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, California, USA.
Yohei TakahashiDivision of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, California, USA.
Alice Y KimPlant Biology Laboratory, Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, California, 92037 USA.
Zixing LiDivision of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, California, USA.
Toshinori KinoshitaDivision of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Joseph R EckerPlant Biology Laboratory, Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, California, 92037 USA.
Julian I SchroederDivision of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USNagoya University · JPSalk Institute for Biological Studies · USHoward Hughes Medical Institute · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
STRESS HORMONE SIGNAL TRANSDUCTION IN ARABIDOPSISR01GM060396 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHROEDER, JULIAN I · 2000 to 2023
$7.4M
Howard Hughes Medical InstituteNIEHS NIH HHS P42 ES010337NIGMS NIH HHS R01 GM060396
6 · The paper itself

Abstract

Abscisic acid (ABA) is a plant hormone that mediates abiotic stress tolerance and regulates growth and development. ABA binds to members of the PYL/RCAR ABA receptor family that initiate signal transduction inhibiting type 2C protein phosphatases. Although crosstalk between ABA and the hormone Jasmonic Acid (JA) has been shown, the molecular entities that mediate this interaction have yet to be fully elucidated. We report a link between ABA and JA signaling through a direct interaction of the ABA receptor PYL6 (RCAR9) with the basic helix-loop-helix transcription factor MYC2. PYL6 and MYC2 interact in yeast two hybrid assays and the interaction is enhanced in the presence of ABA. PYL6 and MYC2 interact in planta based on bimolecular fluorescence complementation and co-immunoprecipitation of the proteins. Furthermore, PYL6 was able to modify transcription driven by MYC2 using JAZ6 and JAZ8 DNA promoter elements in yeast one hybrid assays. Finally, pyl6 T-DNA mutant plants show an increased sensitivity to the addition of JA along with ABA in cotyledon expansion experiments. Overall, the present study identifies a direct mechanism for transcriptional modulation mediated by an ABA receptor different from the core ABA signaling pathway, and a putative mechanistic link connecting ABA and JA signaling pathways.

Indexed as

Signal TransductionAbscisic AcidArabidopsisArabidopsis ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsIntracellular Signaling Peptides and ProteinsLinoleic AcidsNicotianaProtein BindingProtein Interaction MappingTwo-Hybrid System TechniquesAbscisic AcidArabidopsis ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsIntracellular Signaling Peptides and Proteinsjasminic acidLinoleic AcidsMYC2 protein, ArabidopsisPYL6 protein, Arabidopsis

Identifiers

PMID27357749
PMCPMC4928087
OpenAlexW2474448081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.