Evidence map›Paper›PMID 27357530›Full record

ArticleInternational orthopaedics2016

Bone-Albumin filling decreases donor site morbidity and enhances bone formation after anterior cruciate ligament reconstruction with bone-patellar tendon-bone autografts.

Károly Schandl, Dénes B Horváthy, Attila Doros, Ernő Majzik, Charlotte M Schwarz, Lajos Csönge, Géza Abkarovits, László Bucsi, Zsombor Lacza

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in International orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04958733 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Does Bone Grafting at the Time of Bone-Patellar Tendon-Bone ACL Reconstruction Reduce the Incidence of Post-operative Anterior Knee Pain: A Randomized Controlled Clinical Study

TypeinterventionalSponsorHartford HospitalRan2021 to 2024Enrolled60ConditionsACL InjuryArmsAutologous bone grafting, Absence of autologous bone grafting
NCT06975306 narecruitingnot on this mapstarted 2025, after this paper: background citation

Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL Reconstruction

TypeinterventionalSponsorUniversity of ArizonaRan2025 to 2027Enrolled75ConditionsBone Graft, Complications, ACL InjuriesArmsautologous bone grafts, Demineralized bone matrix (DBM)
3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Observational
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  4. Review
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  6. Article
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  12. Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine.International journal of molecular sciences · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. A brief history of tendon and ligament bioreactors: Impact and future prospects.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Károly SchandlInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Tűzoltó u. 37-47, 1094, Hungary.
Dénes B HorváthyInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Tűzoltó u. 37-47, 1094, Hungary.
Attila DorosDepartment of Transplantation and Surgery, Semmelweis University, Budapest, Baross u. 23-26, 1082, Hungary.
Ernő MajzikSaint George University Teaching Hospital of County-Fejér, Székesfehérvár, Seregélyesi u. 3., 8000, Hungary.
Charlotte M SchwarzInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Tűzoltó u. 37-47, 1094, Hungary.
Lajos CsöngeWest Hungarian Regional Tissue Bank, Petz Aladár County Hospital, Győr, Vasvári Pál u. 2-4, 9024, Hungary.
Géza AbkarovitsSaint George University Teaching Hospital of County-Fejér, Székesfehérvár, Seregélyesi u. 3., 8000, Hungary.
László BucsiSaint George University Teaching Hospital of County-Fejér, Székesfehérvár, Seregélyesi u. 3., 8000, Hungary.
Zsombor LaczaInstitute of Clinical Experimental Research, Semmelweis University, Budapest, Tűzoltó u. 37-47, 1094, Hungary. zlacza@mac.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDonor site pain affects 32-43 % of patients after anterior cruciate ligament surgery when the autograft is freshly harvested bone-patellar tendon-bone tissue. Our aim was to compare functional and morphological differences between donor sites with and without serum albumin-coated bone allograft filling.

methodsAfter harvesting and implanting the graft, the tibia site was filled with either fresh autologous cancellous bone enhanced with albumin-coated allograft or autologous bone alone. The patella site was filled either with albumin-coated allograft or with blood clot. Knee function was evaluated by the VISA, Lysholm and IKDC scores and a visual analog scale of pain during standing, kneeling and crouching after six weeks and six months. Computed tomography was performed at six months for morphological evaluation.

resultsAt six weeks, both groups were still recovering from surgery and the overall knee function was still impaired but the functional scores were significantly higher in the Bone-Albumin group. The pain with crouching and kneeling was also lower as compared to controls. At six months, the knee function scores were close to normal, with a slight decrease in the controls. Pain at kneeling was still prominent in the controls, but significantly lower in the Bone-Albumin group. Computed tomography showed significantly smaller bone defects and higher bone density in the Bone-Albumin group.

conclusionsResults from the present study indicate that donor site pain, a disturbing long-term side effect of bone-patellar tendon-bone surgery, is significantly reduced if bone buildup in the patella and the tibia is augmented by serum albumin-coated bone allografts.

Indexed as

Bone TransplantationAdultAlbuminsAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionAutograftsBone-Patellar Tendon-Bone GraftingFemaleHumansKnee JointMaleMiddle AgedOsteogenesisTibiaTransplantation, AutologousTransplantation, HomologousAlbuminsAlbuminAnterior cruciate ligamentBone-AlbuminBone allograftBone-tendon-boneBTBSerum

Identifiers

PMID27357530

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.