ArticleInternational journal of colorectal disease2016
Preoperative inflammation increases the risk of infection after elective colorectal surgery: results from a prospective cohort.
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Trial
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- Preoperative sarcopenia negatively impacts short- and long-term outcomes of rectal cancer: A propensity score-matched analysis.Annals of gastroenterological surgery · 2025Article
- Disregarding C-reactive protein in an inflammation-based nomogram?International journal of colorectal disease · 2025Article
- Effects of Diverting Stoma Creation in Minimally Invasive Surgery for Rectal Cancer.Journal of the anus, rectum and colon · 2025Article
- Achieving Health Equity: Advancing Colorectal Surgery among Racial and Ethnic Minorities in America.Clinics in colon and rectal surgery · 2025Review
- The Impact of Heart Failure Chronic Treatment Prior to Cardiac Transplantation on Early Outcomes.Medicina (Kaunas, Lithuania) · 2024Article
- Association between inflammation-based prognostic markers and mortality after hip replacement.Scientific reports · 2024Article
- Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.Korean journal of anesthesiology · 2023Article
- Safety profile of a multimodal fail-safe model to minimize postoperative complications in oncologic colorectal resections-a cohort study.Perioperative medicine (London, England) · 2023Article
- Risk factor for the development of surgical site infection following ileostomy reversal: a single-center report.Updates in surgery · 2022Article
- Tackling Surgical Morbidity and Mortality through Modifiable Risk Factors in Cancer Patients.Nutrients · 2022Review
- Association between Preoperative hs-crp/Albumin Ratio and Postoperative sirs in Elderly Patients: A Retrospective Observational Cohort Study.The journal of nutrition, health & aging · 2022Observational
- Article
- Closed incision negative pressure wound therapy versus conventional dressings following soft-tissue sarcoma excision: a prospective, randomized controlled trial.Bone & joint open · 2021Article
- The effects of preoperative intestinal dysbacteriosis on postoperative recovery in colorectal cancer surgery: a prospective cohort study.BMC gastroenterology · 2021Article
- Article
- Observational
- Successful Vaginal Delivery during Acute Small Bowel Obstruction: A Case Report and Review of the Literature.Case reports in obstetrics and gynecology · 2021Article
- Assessment of the risk of permanent stoma after low anterior resection in rectal cancer patients.World journal of surgical oncology · 2020Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeptic complications after colorectal surgery are frequent and sometimes life threatening. It is well known that inflammation impairs the healing process. It has been suggested that preoperative ongoing inflammation could increase the risk of postoperative infections. This study aimed to elucidate the role of preoperative inflammation on postoperative infectious complications and to understand if, through biological markers, it is possible to identify preoperatively patients at higher risk of infection.
methodsA prospective, observational study was conducted in three centers from November 2011 to April 2014. Consecutive patients undergoing elective colorectal surgery with anastomosis were included. Any ongoing infection was an exclusion criterion. C-reactive protein, albumin, prealbumin, and procalcitonin plasma levels were measured preoperatively. Postoperative infections were recorded according to the definitions of the Centers for Diseases Control. The areas under the receiver operating characteristic curve were analyzed and compared to assess the accuracy of each preoperative marker.
resultsFour-hundred and seventy two patients were analyzed. Infectious complications occurred in 118 patients (25 %) and mortality in 6 patients (1.3 %). In the univariate analysis, preoperative C-reactive protein and albuminemia were found significantly associated with postoperative infectious complications (P = 0.008 and P = 0.0002, respectively). Areas under the ROC curve for preoperative C-reactive protein and albuminemia were 0.57and 0.62, respectively.
conclusionsThis study confirms the association between preoperative inflammatory activity, hypoalbuminemia, and the onset of infections after surgery. Trials aiming to decrease the inflammatory activity before surgery in order to prevent postoperative complications are warranted.
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