ReviewActa orthopaedica2016
Inter-trabecular bone formation: a specific mechanism for healing of cancellous bone.
Review in Acta orthopaedica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical Reference Strategy for the Selection of Treatment Materials for Maxillofacial Bone Transplantation: A Systematic Review and Network Meta-Analysis.Tissue engineering and regenerative medicine · 2022Pooled it
- The effectiveness and safety of parathyroid hormone in fracture healing: A meta-analysis.Clinics (Sao Paulo, Brazil) · 2019Pooled it
- No effect of teriparatide on migration in total knee replacement.Acta orthopaedica · 2017Trial
- Combining arthroscopic microfracture, autologous bone grafting, and PRP injection for the treatment of Hepple IV-V stage osteochondral lesions of talus.Journal of orthopaedic surgery and research · 2026Article
- Comparative Radiologic Outcomes of Romosozumab and Teriparatide in Osteoporotic Vertebral Fractures.Journal of clinical medicine · 2026Article
- The spinal lymphatic system: an emerging pathway bridging fluid homeostasis, immunity, and disease.Bone research · 2026Review
- Cone-Beam Computed Tomography Evaluation of Bone Density After Sagittal Split Osteotomy Using the Novel Modification of Low Z Plasty Technique.Medicina (Kaunas, Lithuania) · 2025Article
- Strategic Uniaxial Macropore Sizing for Honeycomb-Structured Scaffolds for Enhanced Bone Reconstruction in Segmental Bone Defects.ACS omega · 2025Article
- Time to consider fracture nonunion an orphan disease? An update into pathophysiology, epidemiology and therapeutic solutions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Sixteen patients regarding the conservative treatment for hook of hamate fracture.World journal of orthopedics · 2025Article
- Comparative study of arthroscopic autologous cancellous bone grafting and medial malleolar osteotomy combined with autologous periosteal iliac bone grafting for the treatment of osteochondral lesions of the talus.Journal of orthopaedic surgery and research · 2025Article
- Reverse Shoulder Arthroplasty Baseplate Stability Is Affected by Bone Density and the Type and Amount of Augmentation.Bioengineering (Basel, Switzerland) · 2025Article
- Design of a porous biodegradable internal fixation for the treatment of pauwels type III femoral neck fractures.Frontiers in bioengineering and biotechnology · 2025Article
- Volumetric Humeral Canal Fill Ratio Effects Primary Stability and Cortical Bone Loading in Short and Standard Stem Reverse Shoulder Arthroplasty: A Biomechanical and Computational Study.Journal of imaging · 2024Article
- Trabecular Bone Remodeling After Posterior Lumbar Interbody Fusion: Comparison of Three-Dimensional Porous Tantalum and Titanium-Coated Polyetheretherketone Interbody Cages.Global spine journal · 2024Article
- A stemless anatomic shoulder arthroplasty design provides increased cortical medial calcar bone loading in variable bone densities compared to a short stem implant.JSES international · 2024Article
- Forces required to dynamize sliding screws in gamma nail and selfdynamizable internal fixator.BMC musculoskeletal disorders · 2024Article
- Treatment with Raloxifene Induces the Expression of Kisspeptin, Insulin, and Androgen Receptors in Bones of Castrated Adult Female Rats.Revista brasileira de ortopedia · 2024Article
- Non-Union Treatment in the Foot, Ankle, and Lower Leg: A Multicenter Retrospective Study Comparing Conventional Treatment with the Human Allogeneic Cortical Bone Screw (Shark ScrewJournal of personalized medicine · 2024Article
- The association between body roundness index and osteoporosis in American adults: analysis from NHANES dataset.Frontiers in nutrition · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose - Studies of fracture healing have mainly dealt with shaft fractures, both experimentally and clinically. In contrast, most patients have metaphyseal fractures. There is an increasing awareness that metaphyseal fractures heal partly through mechanisms specific to cancellous bone. Several new models for the study of cancellous bone healing have recently been presented. This review summarizes our current knowledge of cancellous fracture healing. Methods - We performed a review of the literature after doing a systematic literature search. Results - Cancellous bone appears to heal mainly via direct, membranous bone formation that occurs freely in the marrow, probably mostly arising from local stem cells. This mechanism appears to be specific for cancellous bone, and could be named inter-trabecular bone formation. This kind of bone formation is spatially restricted and does not extend more than a few mm outside the injured region. Usually no cartilage is seen, although external callus and cartilage formation can be induced in meta-physeal fractures by mechanical instability. Inter-trabecular bone formation seems to be less sensitive to anti-inflammatory treatment than shaft fractures. Interpretation - The unique characteristics of inter-trabecular bone formation in metaphyseal fractures can lead to differences from shaft healing regarding the effects of age, loading, or drug treatment. This casts doubt on generalizations about fracture healing based solely on shaft fracture models.
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