ArticleJournal of bone and mineral metabolism2017
The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength.
Article in Journal of bone and mineral metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Oral Supplementation ofDentistry journal · 2026Article
- Tart Cherry Supplementation Has Greater Osteogenic Effect on Adult and Aging Bone of C57BL/6 Female Mice than Treadmill Running.The Journal of nutrition · 2026Article
- The Effect of Exercise on Mesenchymal Stem Cells and their Application in Obesity Treatment.Stem cell reviews and reports · 2024Review
- Effects of acute- and long-term aerobic exercises at different intensities on bone in mice.Journal of bone and mineral metabolism · 2024Article
- Moderate intensity aerobic training reduces the signs of peripheral sensitization in a mouse model of type 2 diabetes mellitus.Experimental brain research · 2022Article
- Effects of exercise on the expression of long non-coding RNAs in the bone of mice with osteoporosis.Experimental and therapeutic medicine · 2022Article
- The effects of locomotion on bone marrow mesenchymal stem cell fate: insight into mechanical regulation and bone formation.Cell & bioscience · 2021Review
- Effects of high-intensity interval training in more or less active mice on biomechanical, biophysical and biochemical bone parameters.Scientific reports · 2021Article
- Multiple Applications of Different Exercise Modalities with Rodents.Oxidative medicine and cellular longevity · 2021Review
- Effect of regular resistance exercise, vitamin D, and calcium supplements on the bone mineral content and density in postmenopausal model of rats: An experimental study.International journal of reproductive biomedicine · 2021Article
- Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss.Scientific reports · 2020Article
- Impacts of exercise interventions on different diseases and organ functions in mice.Journal of sport and health science · 2020Review
- Medium-Intensity Treadmill Exercise Exerts Beneficial Effects on Bone Modeling Through Bone Marrow Mesenchymal Stromal Cells.Frontiers in cell and developmental biology · 2020Article
- Use of adult mesenchymal stromal cells in tissue repair: impact of physical exercise.American journal of physiology. Cell physiology · 2019Review
- The effect of testosterone itself and in combination with letrozole on bone mineral density in male rats.Journal of bone and mineral metabolism · 2019Article
- Multiscale experimental study on the effects of different weight-bearing levels during moderate treadmill exercise on bone quality in growing female rats.Biomedical engineering online · 2019Article
- Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise is beneficial to bone health. However, little is known how different intensities of exercise affect bone mass and strength. In the present study, we used young mice to study the effects of different intensities of exercise on bone mass and bone strength in comparison to pharmacological doses of active vitamin D (calcitriol). We found that only the medium level of exercise tested showed a positive effect on bone mineral density, trabecular bone volume, and bone strength, which are attributable to a decrease in bone resorption and an increase in bone formation, with the latter being accompanied by an increase in the number of osteogenic mesenchymal stem cells in the bone marrow. Calcitriol increases bone volume and bone strength, yet the combination of calcitriol and medium-intensity exercise did not further improve bone mass or strength. Moreover, calcitriol also showed some protective effect on the bone in mice with high levels of exercise. These results indicate that exercise at medium intensity increases bone mass and strength via affecting both bone formation and resorption and that its beneficial effects on bone mass cannot be further improved by calcitriol.
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